The first choice of antibiotics for antibacterial treatment of Streptococcus pneumoniae pneumonia is penicillin antibiotics, and considering its resistance, more compound preparations, like amoxicillin clavulanate potassium, piperacillin sodium tazobactam, etc. should be applied reasonably under the guidance of doctors. Sputum culture as well as drug sensitivity test should also be repeatedly performed to clarify the causative organism, the direction of treatment, the application of penicillin antibiotics at the same time preferably with quinolone antibiotics, etc. for review and treatment of refractory streptococcal pneumonia. You can also choose drugs such as aminoglutethimide and acetylcysteine effervescent tablets to dissolve phlegm. For patients with severe wheezing, aminophylline or dihydroxypropyl theophylline or doxorubicin can be added to dilate the airway, which is also very helpful to improve the condition.