Mesenchymal tumors can survive for a long time if they are completely cured. Whether mesenchymal tumor can be cured and how long advanced tumors can live need to take into account the malignancy degree of mesenchymal tumor, tumor size, metastasis degree, treatment method and other factors. Mesenchymal tumors are more common in the gastrointestinal tract. Generally speaking, if the patient has good basic health and is in the early stage of mesenchymal tumor without metastasis, generally after active surgical treatment, some patients can achieve complete eradication and will not affect their life expectancy. However, if the patient has developed metastasis, or if surgical treatment is not possible due to the specific site of tumor growth, the patient’s prognosis is poor, and the 5-year survival rate usually does not exceed 35%. Some patients can also clearly shrink their tumors through targeted therapy, transforming them from unresectable to resectable and greatly improving their survival rate. With the advent of targeted drugs and new drugs, more and more patients have begun to benefit and their survival has been extended. In conclusion, how long a mesenchymal tumor patient can live varies from person to person. Adjusting the mindset, early diagnosis and timely treatment can help improve the prognosis and prolong survival.