How long you don’t need to change medicine after perianal abscess surgery depends mainly on the specific decision of the recovery of the perianal abscess condition. For small abscesses that are relatively minor after perianal abscess surgery, there is basically no need to change medication in about 3 weeks. For larger perianal abscesses or slower recovery after surgical incision and drainage, drug changes are needed for 3-4 weeks after perianal abscess surgery, and sometimes it takes more than a month to fully heal in severe cases. After perianal abscess surgery, you must go to a regular anorectal surgeon for regular drug changes, and you should clean the abscess cavity or exudate necrosis thoroughly at each drug change, which can effectively stimulate the perianal granuloma to continue to grow, which is conducive to the rapid healing of perianal abscess and reduces the time for drug changes. After perianal abscess surgery, you must regularly go to a regular doctor for routine drug changes, and you must not blindly change your own drugs at home to avoid delaying your condition.