1.Palpable or non-fading lumps on the breast, skin, tongue or other parts of the body. 2.Significant changes in warts (superfluous tumors) or moles (e.g., deepening of color, rapid increase in size, itching, hair loss, gangrene, ulceration, bleeding). 3.Persistent indigestion. 4.Choking sensation of swallowing food, pain, stuffy eye discomfort behind the sternum, foreign body sensation in the esophagus or epigastric pain. 5.Tinnitus, hearing loss, nasal congestion, epistaxis, blood in the nasopharyngeal secretions from aspiration and coughing, headache, neck lumps. 6.Unusual heavy bleeding during menstruation, irregular vaginal bleeding during menstruation or after menopause, contact bleeding. 7.Persistent hoarseness, dry cough, blood in sputum. 8.Unexplained blood and mucus in stool or alternating diarrhea and constipation, unexplained hematuria. 9.Wounds and ulcers that do not heal for a long time. 10.Understood weight loss for a longer period of time.