Kidney disease is one of the invisible killers threatening global public health, not only is it very common, but has become a new epidemic. At present, the prevalence of chronic kidney disease in China’s general population is close to 10%, and up to 18.7% in people over 40 years old, which means that 1 in 10 people suffer from chronic kidney disease. However, due to the insidious clinical manifestations of chronic kidney disease, it is often not easy to detect early, and the patient’s own awareness rate is less than 10%, resulting in the loss of the best time for treatment. Most kidney diseases do not have any uncomfortable symptoms in the early stage, and half of the patients with uremia are only found at the initial diagnosis. By this time, they can only rely on hemodialysis, peritoneal dialysis or kidney transplantation to sustain the rest of their lives, and the financial burden of treatment is large. Regular checkups are undoubtedly the best way to detect kidney disease early. The examination mainly includes the following 5 items: blood pressure, blood routine, urine routine, kidney function and kidney ultrasound. They provide preliminary diagnostic information of kidney from multiple aspects and cannot be replaced by each other. They are important, essential and yet the easiest and most economical tests for kidney disease screening. Kidney disease and hypertension are very closely related. The two diseases are often “inseparable” from each other. Hypertension itself can cause kidney damage. The kidneys are mainly composed of glomeruli, which are actually a network of capillaries. If the blood pressure is elevated for a long time, it will cause damage and sclerosis of the capillary walls, resulting in ischemia of the kidneys, which will lead to the decrease of kidney function. Meanwhile, kidney disease itself can also cause hypertension. The incidence of hypertension among patients with chronic kidney disease is high, and the hypertension caused by kidney disease is also known as renal hypertension. According to statistics, renal hypertension accounts for 5-10% of the total number of hypertension, and is the first cause of secondary hypertension. It can be seen that hypertension and renal disease are mutually causal, and poor control of either aspect will cause a vicious circle. Routine blood test is one of the three routine tests, which can provide many useful information. Anemia is often manifested in the advanced stage of chronic kidney disease. Abnormal urinalysis is one of the main manifestations of kidney disease. In most cases, a routine urinalysis test can tell the story and is relatively inexpensive, providing very useful clues for the diagnosis of kidney disease. Ultrasound is also a familiar test, through which we can understand the size, shape, presence of stones, fluid and cysts of the kidney, providing valuable information for diagnosis and judgment of the disease. Therefore, the above routine examinations can provide very useful clues of kidney disease, and timely consultation and consultation with a nephrologist can win the time for correct and reasonable treatment.