Vitamin E is a fat-soluble vitamin, there is no clinical statement that vitamin E is not suitable for taking at night, patients can choose to take it at any time of the day. Patients are advised to choose the time of day and dosage of vitamin E under the guidance of their doctor. It is usually recommended that patients take vitamin E after meals, vitamin E preparations for the absorption of drugs in the small intestine, if taken before meals may stimulate the patient’s gastrointestinal function, in addition to the fat environment is conducive to the absorption of vitamin E, so it is recommended that the patient to follow the instructions of the doctor to take vitamin E. If there are patients with digestive dysfunction such as hepatitis, cholecystitis, bile excretion abnormalities that may cause fat metabolism abnormalities, may affect the absorption of vitamin E, the patient can choose to take vitamin E at any time of the day. It may affect the absorption of vitamin E, need to follow the doctor’s advice reasonable supplementation. In addition, anemia in preterm infants can also be treated by oral vitamin E. Since vitamin E is a fat-soluble vitamin, it is easy to be poisoned by overdose, and it is recommended that patients do not take large amounts of vitamin E for a long period of time, as it may cause coagulation dysfunction, nausea, vomiting, impaired vision, breast enlargement and other adverse reactions.