In recent years, the incidence of malignant tumors has been on the rise. The World Health Organization (WHO) announced that in 2000, there were 10 million patients with malignant tumors in the world, and 6.2 million died of this disease, accounting for 12% of deaths. The mortality rate is also on the rise, topping all major diseases. At present, surgery, radiotherapy, biologic targeted therapy and other comprehensive treatments have been applied to tumor patients, traditional Chinese medicine also plays an important role in the treatment of malignant tumors, and according to statistics, nearly 1/3 of tumor patients have received Chinese medicine treatment during the whole treatment process. According to Chinese medicine, the development of malignant tumors is closely related to “deficiency”, “phlegm” and “stasis”. And “internal deficiency” is the main factor in the development of malignant tumor. As the Nei Jing says, “If the righteousness exists within, evil cannot dry up”. The Ling Shu Jing “wind and rain, cold and damp, not deficiency, evil can not hurt people alone. This must be due to the wind of the deficiency of evil and its body form two deficiency is to get its form.” On the basis of internal deficiency, internal and external factors work together to cause disharmony of yin and yang in the body, dysfunction of the internal organs, stagnation of qi, blood stasis, phlegm and dampness, resulting in lumps. Therefore, the treatment mostly adopts methods such as tonifying deficiency and supporting the righteousness, resolving phlegm and resolving stasis. However, at present, the treatment of tumors by Chinese medicine is still limited to the reduction of toxicity and effectiveness of western medical treatments such as surgery and radiotherapy, while the reduction and even the cure of tumors have not yet achieved satisfactory results. Therefore, some medical practitioners believe that the above explanation of etiology can hardly reflect the essential characteristics of malignant tumors, and it is difficult to achieve satisfactory results in clinical practice based on the above theories alone. Therefore, in recent years, more and more medical practitioners are concerned about “poisonous evil” causing cancer and “treating cancer from poison”. In Chinese medicine, poisonous evil is a widespread pathogenic factor. In Su Wen? In the “Treating Cancer from Toxic Evil”, more and more medical practitioners are concerned about it. Stabbing Method” qi Zheng qi exist within, evil cannot dry, avoid its poisonous gas “. It can be seen that the concept of poisonous evil in the Nei Jing refers to the strong disease-causing effect of evil qi, which is very poisonous to the human body, and is a special cause of disease that is different from the six. Most of the diseases are caused by the rampant poisonous qi, and all the poisons are most likely to cause tumors. Nowadays, more and more scholars put forward the concept of “cancer toxicity” causing cancer, and believe that “cancer toxicity” is the root of malignant tumor, and “cancer toxicity” is the main contradiction or contradiction in the process of occurrence and development of malignant tumor as a special disease. It is the main contradiction or the main aspect of contradiction in the process of occurrence and development of malignant tumor, and should be the main focus of understanding and treatment of malignant tumor. These suggest that we should conduct more in-depth research on the etiology and pathogenesis of malignant tumors in order to make a breakthrough in the treatment. 1. The concept of “cancer toxicity” 1.1 Meaning of “toxicity” In the Eastern Han Dynasty, Xu Shen’s “Shuowen Jiezi” (The Interpretation of the Chinese Language) was written in the same way as the Chinese language. Xu Shen’s “Shuowen Jiezi” says: “Poison, thick, is also harmful to people’s grass, often and born from poison.” Here, “poison, thick,” describes the effect is intense; “harmful grass,” indicates a disease-causing substance; “often,” the appearance of luxuriant; “from the middle ( The meaning of “poison” is a word that refers to the grass that has a strong pathogenic effect. The meaning of “poison” is mainly summarized in three aspects, one is a general reference to the toxicity and partiality of drugs or medicines for treating diseases, Ming? Zhang Jinyue, “The Classical Scriptures? Diseases? The five organs of the disease gas law”: “medicine to cure disease, because of the poison for the ability, the so-called poison, to the smell of the bias. Cover the odor of the right, the genus of grain and food is also, so nourish people’s righteousness; its taste of bias, the genus of medicine and bait is also, so dispel people’s evil, its for the reason also. The disease of man, the disease in the yin and Yang, and want to save its bias, but the odor of the bias can be, is not as good as the positive”. Jin? Zhang Congzheng’s “Confucianism” also refers to drug-induced disease (i.e. toxic side effects) as “drug evil”, also known as drug poison. The second refers to the evidence of disease, mostly in surgery, such as Dan Poison; the third refers to the cause of disease, including a variety of disease-causing substances that can produce toxic or poisonous effects on the body. In a broad sense, it refers to all kinds of substances that can cause violent diseases; in a narrow sense, it refers to the “evil poison” of the six sexes. In the narrow sense, it refers to the “poison of evil”, i.e. when the evil is too strong and reaches a certain level, causing serious damage to the organism, it becomes poison. 1.2 Toxic evil and cancer toxin 1.2.1 Toxic evil can be considered as the toxin of the cause of disease, including external and internal toxins. External toxins include chemical factors, toxins from pollution of living environment, various toxins in diet, etc.; internal toxins include phlegm, dampness, stagnant blood and other pathological products accumulated in the body for a long time, resulting in phlegm, dampness and fatigue toxins. 1.2.2 Cancer toxin Professor Zhou Zhongying believes that cancer toxin is a specific pathogenic factor leading to the occurrence of tumor and is one of the toxic evils. It is a kind of disease evil with obvious harm to human body based on the dysfunction of human internal organs under the action of many factors, which has the characteristics of proliferation, infiltration, recurrence and flow. “Poisonous evil” has its unique characteristics: firstly, it is severe: it is strong in causing disease and serious in harming people, even though they are physically strong and healthy; secondly, it is stubborn: poisonous evil coagulates qi and blood, sticks around and is difficult to be cured; thirdly, it is concurrent: poisonous evil is often concurrent with disease, such as damp-heat poison, phlegm-damp poison, etc. “Poisonous evil is closely related to the occurrence of cancer. Because of its special nature of causing cancer disease, it is also called “cancer toxin”. 1.3 Generation of cancer toxin The generation of cancer toxin is a complicated process, which has been recorded by ancient medical practitioners for a long time, and is considered to be in three aspects: Firstly, cancer toxin is an external guest, for example, in Ling Shu? For example, in “The Nine Needle Treatise”: “The guest of the eight winds of the four seasons is in the meridians, which is also a tumor disease”. Ling Shu? The beginning of all diseases”: “The birth of accumulation is the result of cold, and the syncope is the result of accumulation”. This means that the eight winds of the four seasons, cold (evil), heat, wind and poison can directly cause cancer. Secondly, qi stagnation and depression: for example, “Ge Zhi Yu Lun” points out that “the accumulation of anger and depression, spleen temper and liver qi stagnation, thus becoming hidden nucleus …… also known as breast rock.” The famous doctor’s guide says: “compartment disease mostly starts from depression, depression then gas in the chest compartment and phlegm, for a long time the phlegm knot into a block, gum in the upper jiao, the road is narrow, can’t be wide and smooth, drink can enter, food is difficult to enter, and the disease has become carried.” Suggests that the occurrence of tumors such as breast rocks and choking compartment is related to the seven emotions and depression poison. The first is that the person who is in the middle of a tumor is the one who is in the middle of a tumor. …for a long time will accumulate as Y obstruction.” Poor diet, addiction to wine, addiction to cold and sorghum can damage the spleen and stomach and lead to tumor development. If the nature of external poison is Yang, Yang poison will invade the body and add with Yang of the person to become heat poison, which will easily deplete Yin and show the signs of heat poisoning; if the nature of external poison is Yin, it can curb the Yang of the body and start to show the signs of cold when Yin is strong, which will develop in two aspects: one is depression for a long time to form Yin toxicity, and the second is that the cold and depression turn into heat and become heat toxicity. The evil toxin and the pathological products of blood stasis, phlegm and dampness are intertwined, and the stagnation is difficult to be transformed and accumulate, which becomes cancer after a long time. Cancer toxicity is mostly caused by phlegm, dampness, stasis and fire, so there are heat toxicity, phlegm toxicity, dampness toxicity and stasis toxicity. 1.5 Characteristics of cancer toxin 1.5.1 Cancer toxin is different from general evil energy, it is a “new species” produced by alienation of normal tissues of the body under the action of various pathogenic factors, which is highly destructive to the body and has great toxicity. 1.5.2 Cancer toxin is different from other inanimate pathological products such as phlegm stagnation and qi stagnation. It is a living organism that needs nutrient supply and can easily deplete the body’s vital energy. 1.5.3 Cancer toxin is inextricably linked with normal tissues, and the commonality between cancer toxin tissues and normal tissues and cells is much greater than their differences, which often form a situation of common prosperity and common loss in the treatment process. In the clinical treatment of cancer, it is often seen that attacking evil means hurting righteousness (e.g. chemotherapy attacks poison with poison), and supporting righteousness also helps evil (e.g. animal test proves that ginseng can promote the growth of tumor); it often forms a situation where righteousness flourishes and evil also flourishes, and evil hurts and declines, which is difficult to be solved. 1.5.4 Unlike foreign microorganisms, cancer toxins often accumulate and form living tissues, and create local veins and channels in the tumor, robbing nutrition and making the tumor grow indefinitely; at the same time, the tumor destroys the surrounding organs and meridians and obstructs qi flow. At the same time, cancer accumulation destroys the surrounding organs and meridians and obstructs qi flow. 1.5.5 Cancer toxin not only grows indefinitely locally, but also flows through the meridians, forming cancer accumulations of different sizes in various parts of the body, causing the body to have empty veins and channels, congestion of qi and depletion of positive qi. 1.5.6 Cancer toxin is more resistant than normal organs to “poisonous drugs” and often develops tolerance (multi–drugresistance, MDR) to different drugs at the same time, which often results in “attacking poison with poison” treatment. This often results in the treatment of “attacking poison with poison”, which hurts the righteousness and fails to dispel the evil, resulting in the flourishing of evil and the exhaustion of righteousness. For example, cancer cells can rapidly secrete a large number of drug-resistant proteins and form tissue resistance, leading to failure of chemotherapy, while the side effects of chemotherapy can cause serious damage to the body. 1.5.7 The theory of vasovirulence and accumulation of cancer toxins (Zhongzangjing? On Canker Sores and Swellings (41) says: “Canker sores and swellings are caused by the non-flow of toxins in the five organs and six bowels, not only by the congestion of the Ying and Wei. The main causes of malignant tumors are: exogenous factors (chemical carcinogens, mycotoxins, carcinogenic viruses, etc.) and endogenous factors (genetics, etc.), and cancer toxin includes all exogenous carcinogenic factors, and its long-term accumulation of carcinogenic characteristics is called voodoo in Chinese medicine. Malignant tumors are formed by multifactorial, multi-step and multi-gene events accumulating over a long period of time, therefore, cancer toxicity includes all exogenous cancer-causing factors, and its long-term accumulation of cancer-causing characteristics can be called “volatile toxicity” in Chinese medicine. The long-term accumulation of volatile toxin causes genetic mutation of normal cells in the body, which eventually turns into cancer cells and escapes from immune surveillance to form nodal toxin. Once it is formed, it is difficult to be cured, and it is easy to recur and has a very poor prognosis. It is insidious, proliferative, infiltrative, effusive, stubborn, and easily injures the righteousness. When the body is deficient in vital energy, it cannot restrain the cancerous toxin, or the cancerous toxin is fierce and the vital energy does not prevail over the evil, the cancerous toxin flows through the meridians and shed in other places, commonly offending the bone, liver and brain, and metastatic cancer appears. 2.1 Phlegm, heat and fatigue are embedded in the tumor 2.1.1 Heat poison: According to Gu Songyuan of the Qing Dynasty, “Smoke is the leader of pungent heat, which can hurt yin”. Long-term smoking, heat toxin is contained within; in addition, the six sexes and seven emotions can turn into fire, phlegm and fatigue can turn into heat over time, heat and fatigue can turn into heat toxin over time, heat toxin stays in the body, breeding cancer toxin, gradually grow into a block and become a product. As it is said in the “Renzai Direct Instruction with Remains”, “cancer is high up and deep down, like a rock cave, and the heat poison is deeply hidden”. According to Prof. Yu Rencun, tumors are formed by internal heat (fire), blood condenses when it meets fire, fluid burns when it meets fire, and gas, blood and phlegm congestion block the meridians and internal organs, thus forming tumors. Tumor can be caused by depression, depression and fire, depression and fire with blood clotting. Clinical cancer patients mostly see the evidence of heat-depression and fire-poison, such as the arrogance of evil heat, showing the evidence of real heat, indicating that the tumor is developing, which is a sign of disease advancement. If the disease is prolonged and the body is weak, the toxin is trapped inside, the disease turns from yang to yin and becomes the evil of yin and toxin, then yin sores and gangrene will be formed, the flesh will be rotten and black, and the juice will be clear and thin. 2.1.2 Phlegm poisoning: phlegm can be produced by smoke poisoning of the lungs, internal injury to the emotions, resulting in the loss of lung declamation and descent, poor qi flow, abnormal transmission of fluids brewed into phlegm; or weakness of the spleen and stomach, water and grain can not be transported, and become phlegm; or fire and heat burning fluids for phlegm, phlegm knotted for a long time, brewed into evil poison, phlegm poisoning internal ambush and become accumulation. 2.1.3 Stasis poison: Stasis poison can be produced by poisonous evil directly affecting blood, or by non-poisonous evil factors affecting qi flow, resulting in qi stagnation and blood stasis, blood stasis for a long time, can be from cold to poison, or from heat to poison, becoming stasis poison. As stated in the Treatise on the Origin of Diseases: “Blood stasis within the body, sometimes the body becomes hot and yellow, and if the stasis does not subside for a long time, it will become accumulation of Y obstruction”. 2.2 “Cancer toxin” causes “cancer” and “deficiency”. It is believed that most diseases are caused by deficiency and deficiency causes reality. Cancer toxin and its pathological metabolites spread to the whole body through the circulation of blood and lymphatic fluid, resulting in overall dysfunction, and then depleting the vital energy, and entangling with qi, blood, phlegm and heat to further produce a series of pathological changes. For example, if cancer toxin is contained in the body, fluid is not distributed smoothly and becomes phlegm; if cancer toxin is trapped in the body, it blocks qi flow and blood flow is not smooth, which leads to stasis; if cancer toxin depletes vital energy, qi deficiency cannot promote blood flow and blood flow is slow, which also leads to stasis; if cancer toxin is entangled with phlegm and stasis, it often turns heat into stasis, which leads to internal congestion of heat toxin; if cancer toxin is trapped in the middle jiao, it leads to failure of spleen and stomach to transport and transform water, grain and fluid, which leads to internal growth of dampness; if cancer toxin is trapped in the body, it keeps robbing It leads to deficiency of vital energy and vital fluids in the internal organs, which in turn leads to rapid growth, spread and metastasis of malignant tumors, thus forming a vicious circle. 2.3 “Cancer toxicity” causes tumor recurrence and metastasis Cancer toxicity is the direct cause of cancer tumor formation and development, and is also an intrinsic factor causing recurrence and metastasis. In the early stage, cancer toxin mainly manifests itself as invasion and spread around the primary lesion; in the middle stage, cancer toxin spreads along the channels and meridians, and metastatic lesions will be formed again under suitable environment; cancer toxin overflows and consumes positive qi, and the power of both sides will be weaker and weaker, the tendency of cancer toxin to spread is stronger and stronger, forming a vicious circle, and gradually entering the advanced stage. 3.Treating cancer from “poison” Once cancer poison is formed, it has the characteristics of rapid growth, spread and flow, etc. It is necessary to take the means of attacking poison with poison in time to eliminate cancer poison to the maximum extent. Especially in the early stage of the disease, when the positive energy is not yet decayed and the cancer toxin is also in full bloom, we should increase the strength to kill the toxin directly. The application of antidotes for cancer is described in the Song Dynasty’s Dongxuan Jushi’s “Wei Ji Bao Shu? The first is cancer, but the first cancer has no clue, only the flesh is hot and painful. After one seven or two seven, suddenly purple red slightly swollen, gradually no pain, escape traces of soft cooked purple red, but not broken. It is advisable to put down a large car ao san to take it. Then take pus detoxification, defeat poison, tori, internal tonic and other dispersions. After the break with addictive incense paste paste. The five pills are used to remove wind and Qi.” It is mentioned that the agent of defeating poison is applied to treat cancer. Later it says: “The disease of carbuncle and gangrene, such as the source of water in the mountains, a night surge, non-determined its main meeting, the branch of the large channel, so as to kill its potential, then the horizontal scribble for disaster. Fierce disease, with a fierce column of medicine, this is called attacking poison with poison.” “Attacking poison with poison” is none other than “insect medicine” and “poison medicine”, directly attacking poison and reaching the disease. For heat poison, phlegm poison, stasis poison, etc., treatment is given to clear heat and detoxify, resolve stasis and detoxify, resolve phlegm and detoxify. Commonly used are Bajiao Lian, Shi Shangbai, Sheng Hanxia, Tiannanxing, Xijie, Sanliao, Shui Frog, Earth Turtle Worm, Pierced Mountain Nail, Whole Scorpion, Amusement Ant, Dried Toad Skin, Lu Hifang, Wu Zhui Snake, White Flower Snake, Half Lotus, White Flower Snake Tongue Herb, Bitter Ginseng, etc. The meaning of “attacking poison with poison” is not only limited to the internal and external treatment of Chinese medicine, but also includes the treatment by modern medical means, including surgery, radiotherapy, chemotherapy and local treatment means (such as TACE, hydrogen helium knife freezing, radiofrequency ablation, intratumoral injection of anti-cancer drugs, etc.). “If we insist on fighting poison with poison and destroying it, it will damage the vital energy and make the cancer poison come back, which will be counterproductive. Especially in the middle and late stage of the disease, when the patient’s righteousness has already declined and the cancerous toxin is also in full bloom, it is more important to adopt both attack and supplementation to support the righteousness and eliminate the evil.