Coronary heart disease is a chronic disease, currently in the clinic, the vast majority of patients are taking long-term medication, of which aspirin and statin are the most familiar drugs, but because patients with coronary heart disease are often comorbid with other diseases, so in the clinical use of medication will need to randomize, or increase or decrease the type and dose of the drug, and many times need to be applied in combination. Coronary heart disease combined with other diseases of drug selection! 1.Coronary heart disease combined with hypertension The treatment goal is to reduce blood pressure, reduce myocardial ischemia, relieve uncomfortable symptoms, etc. Because the blood supply of coronary vessels mainly depends on diastolic blood pressure, diastolic blood pressure is too low may occur in the occurrence of coronary artery insufficiency of blood supply, so that the chances of adverse events become higher, so for this kind of patients, it is not recommended that the diastolic blood pressure control is too low, it should be higher than 65mmHg, at about 70mmHg. Coronary artery disease patients have more subtypes, if it is stable angina combined with hypertension patients recommended β-blockers, long-acting calcium antagonists, ACEI; acute infarction recommended ACEI, β-blockers, aldosterone antagonists. 2.Coronary heart disease combined with diabetes mellitus This kind of patients due to the combination of diabetes and coronary heart disease, will make the condition become complex and serious, in the clinic of this kind of patients stent stenosis after the chance is significantly higher than others, this is because the diabetes of the lesion lies in the microvessel, and coronary heart disease is the main lesion in the coronary artery, the combination of the two will be mutual promotion and influence. The vast majority of patients with combined coronary artery disease should consider ACEI or ARB for treatment to reduce the risk of adverse events, if the patient is infarction, should be long-term application of β-blockers, as for the application of the more common metformin need to be careful, for example, stable congestive heart failure patients, eGFR greater than 30 ml/min can be applied, but if unstable is not recommended to apply. Drug selection for the stage of coronary heart disease! 1, sudden phase: Nitroglycerin: should be immediately sublingual 0.6mg, the interval of 5 minutes can continue to contain (no more than 3 times), the effect is not obvious need intravenous nitrate drugs. Antiplatelet drugs: 160-325mg of aspirin should be chewed and taken immediately; if aspirin resistance, clopidogrel is used or combined with it. 2.Acute stage: Antiplatelet drugs: aspirin is preferred; clopidogrel is chosen if contraindication exists. Anticoagulant drugs: ordinary heparin, low molecular heparin. Antianginal drugs: β-blockers, nitrates, calcium antagonists, opioids. 3.Stable stage: Antiplatelet drugs: aspirin, clopidogrel, angiotensin-converting enzyme inhibitors Antianginal drugs: β-blockers, nitrate, calcium antagonists. Lipid-regulating drugs: statins. For patients, the choice of drugs is never simple, there are many factors affecting its effect, in the clinic, I never recommend blindly using drugs, should be based on their own situation and reasonable choice of drug types and dosage, in order to maximize the effectiveness of the drug, reasonable and stable control of the development of the disease, to ensure health.