Colitis refers to inflammatory lesions of the colon caused by various causes, which may be caused by bacteria, fungi, viruses, parasites, and also by metabolic reactions and physicochemical factors. Therefore, depending on the cause, the clinical treatment varies, but in principle, it is important to control the symptoms of the disease as early as possible, promote remission, maintain treatment, prevent recurrence, and strictly control the timing of surgical treatment, that is, the indications for surgery. In daily life patients with colitis should pay attention to rest, prevent overwork, eat highly nutritious, easily digestible food, low-fat, low residue food, if severe patients with giant colon or intestinal fistula formation, they should fast and give parenteral and total parenteral nutrition. Medication commonly used aminosalicylates, such as salazosulfapyridine, are indicated for mild and moderate ulcers, intermittent relapse prevention, and dosage is strictly prescribed according to the patient’s different doses. Take strict attention to patients with sulfonamide allergy can not be used, because this drug has hepatic and renal toxicity, three months of continuous use is recommended to review liver function, kidney function, and ketones such as mesalazine, olsalazine, these are ketones drugs, side effects are slightly lower. Glucocorticoids, commonly used drugs such as prednisone and prednisolone, are also effective in suppressing inflammation in the acute active phase of ulcerative colitis. If further severe, such as combined hemorrhage, intestinal perforation or imminent perforation, or toxic colitis, this condition should be treated surgically as an option.