Anxiety, panic, and irritability are often related to emotions and are often due to a series of clinical manifestations caused by sympathetic excitation, which mostly occur in middle-aged women during menopause and perimenopause. Therefore, the treatment of these symptoms can be improved with drugs that reduce sympathetic excitation; they can also be combined with drugs that regulate the vegetative nerves, such as beta-blockers, glutamate and other drugs. The prerequisite is to perform routine tests such as ECG, cardiac enzymes, and cardiac ultrasound to exclude organic lesions before the above treatments can be performed. In addition, it is important to relax, avoid anxiety and tension, and develop good habits. In case of insomnia, palpitations and irritability, sedative and tranquilizing drugs, such as Valium, should be used under medical supervision.