The argon helium knife is not really a scalpel, but a new, ultra-low temperature instrument for tumor treatment. The argon helium knife is shaped like a puncture needle and can be as thin as 2 mm. The argon helium knife is hollow and can circulate high pressure room temperature argon gas (cold medium) and high pressure room temperature helium gas (hot medium). Most of the procedures are performed with local anesthesia, and the argon knife is accurately punctured into the tumor under the guidance of CT or B-ultrasound. The argon gas is activated first, and the rapid expansion of argon gas at the tip of the knife produces a cooling effect, freezing the lesion to minus 140°C~170°C within 15 seconds. After 15-20 minutes, the argon gas is turned off, and then the helium gas is activated, which can be used to rapidly expand at the tip of the knife and rapidly heat the lesion tissue in the ultra-low temperature state, causing the temperature of the lesion tissue to rise from -140℃ to -20℃~40℃, thus performing rapid thermal therapy. After 3~5 minutes, the above treatment will be repeated again. This kind of hot and cold reversal therapy is particularly thorough in destroying the diseased tissues. The speed, time and temperature of cooling and heating, and the size and shape of the destroyed area can be monitored in real time by ultrasound or CT, and precisely set and controlled by computer. More importantly, because argon helium knife cooling or heating is limited to the tip of the knife, the knife shaft does not cause hot or cold damage to the tissue in the puncture path. The Ar-He knife is the only instrument available for minimally invasive percutaneous hot and cold therapy. Compared with conventional methods, Ar-He knife treatment has unique advantages: (1) less damage to the patient and can be performed without incision through the skin or lumpectomy; (2) good success rate; (3) the incidence and severity of complications are much less than conventional surgery; (4) no toxicity to normal tissues, organs and cells, and the patient recovers quickly; (5) minor surgical damage, repeatable and reproducible; (6) remarkable results, easy to operate, low cost, and easy for the patient to accept; (7) easy to use and easy to use. (7) It can be performed alone or in combination with radiotherapy, chemotherapy or surgery; (8) It can be used for patients who cannot be treated by other therapies or whose treatment has failed; (9) The body’s immune system is reactivated by tumor necrotic tissue antigens, which facilitates its own anti-tumor effect and improves the quality of survival.