Plasma replacement is a new blood purification therapy that separates the patient’s blood into plasma and blood cell components outside the body, discards the plasma, and then transfuses the cell components back into the body together with the replacement fluid, thereby removing pathological substances (such as autoantibodies, immune complexes, inflammatory reactive substances, toxic and harmful substances, etc.) from the body to treat diseases. Plasma exchange can be used to treat the following diseases: 1. renal diseases: such as pulmonary hemorrhagic nephritis syndrome, lupus nephritis, purulent nephritis, IgA nephropathy, membrane proliferative nephritis and acute rejection of transplanted kidney, especially vascular rejection. 2. systemic diseases: systemic lupus erythematosus, polyarteritis nodosa, dermatomyositis, rheumatoid arthritis, etc. 3. hematological diseases: autoimmune hemolytic anemia, hemolytic uremic syndrome, thrombotic thrombocytopenic violet epilepsy, hyperviscosity, etc. 4, neurological diseases: diseases for which plasma replacement is indicated include myasthenia gravis, polyneuritis, neurological damage in systemic lupus erythematosus and multiple sclerosis, etc. 5, acute and chronic liver failure: such as fulminant hepatitis, drug poisoning, surgery or trauma, biliary cirrhosis, hepatic coma, etc. 6, others. Hypercholesterolemia, such as severe psoriasis, muscarinic poisoning. Conventional plasma replacement requires a large amount of plasma, which is difficult to be widely used due to the tight blood supply. The plasma-free plasma replacement technology carried out by the Department of Hematology of Taihe Hospital has effectively alleviated this problem, greatly reducing the dependence on plasma, eliminating the need to wait for plasma for a long time and providing treatment for patients at any time, ensuring the timeliness of treatment, improving the therapeutic effect and bringing gospel to patients.