The application of comprehensive therapy is currently advocated. First, a reasonable comprehensive assessment should be made with the medical history and clinical manifestations. Then, the treatment plan should be decided according to the progressive stage, size, texture, and conscious symptoms of the lesion. There are many ways to clinically classify keloid scars, which can be clinically classified according to their morphological differences: superficial keloid scars (also called normal keloid scars), proliferative keloid scars, atrophic keloid scars and keloid scars. Among them, proliferative keloid and keloid are the more common pathological keloid scars in clinical practice. Treatment: i. Silicone gel sheets and compression therapy can be used as a basic adjunctive treatment The materials needed to make an elastic sleeve usually include sponges, plastic sheets, silicone gel or silicone sheets to increase pressure and more apposition to the scar, while preventing damage to the nascent epidermis from the cutting stress. Intradermal glucocorticoid injections as the first line of treatment Hormone injections are most commonly used in the initial stages of keloid treatment. Hormone injections are most effective for hyperplastic keloid scars in the growth phase, but for old keloid scars or keloids, hormone injections can only soften and flatten the scar to varying degrees and improve the symptoms. Third, surgical procedures need to be very strict in mastering the indications, following the operating principles, and timely postoperative supplementation with radiation and other treatments For hyperplastic keloid scars with cosmetic requirements, surgical excision + hormone injection + pressure therapy can be used But surgical procedures are definitely not the first choice for keloid treatment, and the recurrence rate of surgical excision is reported in the literature to range from 45 to 100%. Therefore, surgical excision usually needs to be combined with other treatments, such as hormone injections, superficial radiotherapy, topical silicone gel or compression therapy. In combination with our department, we can use surgical excision + compression therapy + hormone injection or isotope or superficial x-ray radiotherapy. The indications for keloid surgery are divided into absolute indications and relative indications. Absolute indications: ① sinus tracts and pus cavities within the keloid tissue, causing recurrent infections; ② keloid located in the female pubic mound; ③ large keloid on the anterior chest that seriously affects the quality of life; ④ exposed areas, such as the earlobe, upper chest, and shoulder triangle that significantly affect the appearance; ⑤ keloid folliculitis on the collar. Relative indications: ① those with high cosmetic requirements; ② those with long duration of disease, obvious self-perceived symptoms, unsatisfied with other treatments, and scar width (perpendicular to the skin tension line) > 2cm. Laser and cryotherapy With the development of laser technology, laser surgery is quite promising in the treatment of hyperplastic scars and keloids. The mechanism of damage to tissues by freezing and laser is actually the same, both can cause cell damage and disturbance of microcirculation, leading to cellular hypoxia, and their direct consequence is tissue necrosis and detachment. The effect of both treatments is similar, at 51-76%. Cryosurgery is more effective than keloid treatment for early proliferative scarring. V: Drug therapy Some promising drugs include: retinoic acid, trinostat, hexoketocine, calcium channel blockers, H1 histamine receptor antagonists, 5-FU, imiquimod, onion bark extract, Centella asiatica extract preparations, etc.