Plasma cell mastitis is a common disease among women in their reproductive years and occurs during the non-lactating period. Plasma cell mastitis is a chronic non-bacterial infectious benign disease of the mammary gland based on dilatation of the milk ducts and infiltration of plasma cells, and plasma cell mastitis is characterized by the coexistence of lumps, overflow, abscesses and fistulas. The most important thing is that it is not easy to find the best way to treat plasma cell mastitis. Modern medicine mainly uses surgical methods to treat plasma cell mastitis. No matter what kind of surgery is taken, it can lead to a big change in the appearance of the patient’s breast, which seriously affects the quality of life and is difficult for the patient to accept. In Chinese medicine, plasma cell mastitis is known as “acne canker sore”. It is mainly due to congenital insufficiency, internal injuries of seven emotions, dislocation of rushes, and exogenous evils. Through the Chinese medicine identification and treatment, the effect is remarkable, the clinical use of the main grasp of staged treatment, according to the different stages of the disease to take different methods. In Western medicine, plasma cell mastitis is considered an autoimmune disease, and hormone therapy can alleviate the condition and reduce the size of the lesions. Currently, treatment is gradually favoring the combination of Chinese and Western medicine. Based on the pathogenesis, the use of TCM diagnosis and treatment combined with hormone therapy before surgery, combined with surgical treatment, can achieve good results. Narrowing the scope of surgery and reducing postoperative recurrence. This new technology combines the evidence-based treatment in Chinese medicine with hormone therapy in western medicine, which can significantly enhance the curative effect of plasma cell mastitis and maintain the shape of patients’ breasts to a greater extent. It is worthy of clinical promotion and application.