With the continuous improvement of the treatment effect of malignant tumors and the prolonged survival of patients with malignant tumors, the number of bone metastases has been increasing. Many people, including oncologists, believe that once metastasis of bone occurs, the value of treatment is lost. This view is wrong. For single bone metastasis, if the primary lesion is controlled and no other organ metastasis is found, aggressive radical surgery should be performed, followed by systemic anti-tumor therapy (of course, the chemotherapy regimen needs to be adjusted), so that clinical cure can still be achieved. For multiple metastases, while systemic anti-tumor therapy is administered, the need for surgical treatment is decided according to the condition of the patient: for those with pathological fractures in bone metastases of the limbs or nerve compression in vertebral metastases, surgical treatment should be performed to reduce the patient’s pain and preserve the mobility of the limbs, which can significantly improve the patient’s quality of life and increase his confidence in overcoming the disease; for multiple bone metastases with severe pain, palliative microwave ablation can also be chosen. For multiple bone metastases with severe pain, palliative microwave ablation treatment can be chosen to relieve pain, which is mildly invasive and can achieve immediate pain relief. In the surgical treatment of bone metastases, microwave in situ inactivation technology has obvious advantages. By inactivating the tumor, the purpose of tumor control can be achieved, while avoiding the greater trauma and higher cost of conventional prosthesis replacement surgery, and for patients who have lost the opportunity for radical surgery, palliative microwave therapy can also be performed to achieve pain relief.