In slim people with obvious sunken cheeks, the cheek arches are visible as bulging, both cheeks are collapsed, fine wrinkles are visible at the cheeks and corners of the mouth, the skin is dry, and the complexion is yellowish and unattractive. What are the tests related to obvious sunken cheeks? 1.Weight measurement: It should be done regularly and compared with the standard weight to understand whether the weight loss is progressive or not. The common diseases that make the weight loss sharp are diabetes, hyperthyroidism, malignant tumor, etc. 2, for wasting should be measured temperature, blood pressure a heart rate: for long-term fever should consider the possible presence of chronic infection, tumor, connective tissue disease, hyperthyroidism, pheochromocytoma; for those who have hypertension (paroxysmal or persistent) should consider the possibility of pheochromocytoma. 3. Examination of the oral cavity,, skin, hair, lymph nodes, etc.: pay attention to the presence of malnutrition, vitamin deficiency, anemia, edema, etc. In patients with hypopituitarism, skin pigmentation is reduced, hair loss is more obvious in the pubic hair and axillary hair, skin is pale, dry, lusterless and genital atrophy, women have breast atrophy, Adison’s disease has skin pigmentation, lips and oral membranes have pitting blue-black pigmentation, skin is more obvious in exposed areas, pressure and friction areas, early corona, perineum, abdominal white line, etc. Patients with hyperthyroidism have warm, moist and sweaty skin, tremors when extending the tongue and hands, increased heart rate and hyperacusis, and other signs such as goiter and protrusion of the eyes. In carcinoid syndrome, there may be episodes of asthma, skin flushing, right heart murmur and hepatomegaly. Purple spots on the skin, enlarged lymph nodes in bleeding spots, etc. should be considered as possible hematological diseases and malignant tumors. 4. Examination of other systems: such as chest, abdomen and neurological examination are important clues for early diagnosis.