The Chinese word “pain” refers to residual pain; “ache” refers to the hurtful sensation inside the patient’s body. The so-called pain in modern medicine is a complex physiological and psychological activity, which is one of the most common symptoms in clinical practice. It consists of the pain sensation caused by an injurious stimulus acting on the body, and the painful reaction of the body to the injurious stimulus (somatomotor reaction and/or visceral vegetative reaction, often accompanied by strong emotional overtones). Pain is an unpleasant sensory and emotional experience caused by tissue damage or potential tissue damage. Internationally, pain has become the fifth vital sign after body temperature, pulse, respiration and blood pressure. Wu Hao, Department of Neurosurgery, Xuanwu Hospital, Capital Medical University Regarding postoperative pain, most doctors and patients still have the belief that “postoperative pain is normal and unavoidable ……”, “patients should tolerate pain and not complain. ……” and “only severe pain needs to be treated ……”. Currently, these concepts and the plans based on them have become significantly outdated in the international arena. If postoperative pain is not effectively controlled in the initial stage, continuous pain stimulation can cause pathological remodeling of the central nervous system, and acute postoperative pain may develop into chronic pain that is difficult to control. Chronic pain is not only a painful sensory experience for patients, but commonly affects patients’ somatic and social functions seriously, prolongs hospitalization, increases medical costs, and prevents patients from participating in normal life and social activities. Therefore, providing analgesia for the surgical period is an important task facing medical practitioners. Patients with cervical spondylosis are more often operated via the anterior approach, which is characterized by small surgical incisions, minimal bleeding, and direct and adequate decompression. Patients undergoing anterior surgery present with two types of postoperative pain, an acute postoperative pain caused by excessive stretching due to soft tissue injury, but the pain from the surgery itself is lower given that anterior surgery enters through the gap between the trachea, esophagus and carotid sheath, exposing the anterior part of the vertebral body, unlike posterior surgery which requires excessive muscle separation. It is now believed that acute postoperative pain triggers the remodeling of the central nervous system, and the main neural mechanism is the generation of peripheral and central sensitization, while the inflammatory response plays a very important role in the process of nociceptive sensitization, therefore some scholars propose prophylactic analgesia. Based on the above theory, we have given preventive analgesia by taking CILP before surgery, and postoperative analgesia by giving CILP or Trenor for 2-3 days after surgery, and the patients have achieved satisfactory results and almost pain-free (the preoperative neurogenic pain is related to whether the surgical decompression is complete, and if the decompression is sufficient, the patients’ pain will be relieved immediately after surgery; on the contrary, if the decompression is not sufficient, the postoperative analgesic drugs will be ineffective). The second type of pain that occurs in anterior cervical spine surgery is also present in other surgeries in the cervical spine, such as posterior cervical spine surgery and cervical spinal canal tumor, etc. It often appears 1-3 weeks after surgery, and some even lasts for several months, combined with bilateral shoulder pain and discomfort, which some scholars call “axial symptoms”. This kind of pain is often caused by the patient’s postoperative tension, subconsciously thinking that the cervical spine is unstable after surgery, trying to protect it through muscle strength, resulting in fatigue and disorder of the muscle groups of the neck, both shoulders and even both upper limbs, resulting in a series of discomfort and pain. Another reason is that the postoperative cervical brace is worn for too long. Some scholars recommend wearing a neck brace for 3 months, depending on the bony healing time, while others recommend wearing it for one to two weeks. The prolonged wearing of the neck brace results in too little neck movement and fatigue of the neck muscles as well, and some patients even develop neck brace dependency symptoms. For the second type of pain, the author believes that postoperative health education and psychotherapy for patients are extremely important. Because pain is largely influenced by psychological, family, and social factors, during the whole process of pain treatment, medical and nursing staff should use psychological nursing to constantly tell patients that the cervical spine is stable after surgery, teach patients to relax the whole body, especially the neck muscles, and at the same time do a good job of psychological guidance to reduce their anxiety and relieve the sensitizing pain caused by bad emotions. For example, for the wearing of the cervical brace, the role of the author’s cervical brace is to prevent the implanted internal fixation from shifting when the patient is in excessive forward flexion or back extension after surgery, so the wearing of the cervical brace is strictly recommended for one week for patients undergoing simple anterior cervical surgery, but it is recommended to wear the cervical brace when traveling and riding in a car within three months. Distract the patient’s attention, tell the postoperative patient’s neck can be moderately active, chat with him more, let him listen to music, and read newspapers and TV appropriately for those with no visual impairment. It is worth mentioning that for patients who are worried about the adverse effects of pain medication. It should be explained that in the case of strong pain, the use of painkillers is not easy to produce dependence, while the continuous endurance of strong pain will have adverse effects on the organism. Since cervical spine patients are often elderly patients, by improving postoperative pain, we can relieve patients’ tension, thus reducing the incidence of perioperative cardiovascular system complications, making patients dare to breathe deeply and cough, thus reducing the incidence of pulmonary atelectasis and pulmonary infection, and also enhancing patients’ immunity, improving sleep and promoting the recovery of the organism. The neurosurgery spine group of Xuanwu Hospital has been carrying out minimally invasive cervical spine surgery for many years, especially for elderly patients, using multiple channels of analgesia for pain-free management and assessing patients’ pain through preoperative and postoperative pain scores, and the results show that anterior cervical spine surgery can be completely pain-free.