The main function of the spleen is to filter and store blood. At the same time, the spleen is the largest immune organ of the body, accounting for 25% of the total lymphoid tissue in the body, containing a large number of lymphocytes and giant eosinophils, and is the center of cellular and humoral immunity of the body. The spleen is usually not palpable in a normal state, but if the edge of the spleen can be touched in the supine or right lateral position, it indicates splenomegaly. Humans have evolved immune functions in order to combat the effects of foreign or intrinsic negative substances on the body. Once the body recognizes bad molecules in the blood stream, such as various bacteria, viruses, tumors, parasites, etc., it begins to mobilize the body’s immune units to fight. And this main battlefield lies in the spleen. The basic cause of immune thrombocytopenia lies in the fact that platelets, which are a normal component of the body, are mistaken for bad molecules. The process of misidentification is very complex, here is a simple example to illustrate for your understanding, our body is very intelligent for foreign bad molecules to identify, first of all, this bad molecule is dismantled, this is a leg, that is an arm, similar to this, and then there are antigen-presenting cells, equivalent to the police workers out on the scene to these arms and legs to B lymphocytes, equivalent to forensic science, let forensic science The B lymphocytes to take pictures, is to make antibodies, and then let the immune cells against the photos to attack the bad guys. In a patient with immune thrombocytopenia, his immune cells get a picture, for example, of an arm that looks like his own platelet arm, and then his own platelet suffers. This is how the disease arises. In the vast majority of immune thrombocytopenia, humoral immunity is predominant, and with fewer photos, the attack by immune cells on the platelets is greatly reduced, and the disease is then controlled. However, the efficacy of splenectomy in immune thrombocytopenia is not 100%, that is, in some patients with immune thrombocytopenia the main site of immunity is not the spleen, and the literature has confirmed that in some patients the main sites of platelet destruction are in the liver and lymph nodes, so the efficacy of splenectomy in such patients is poor.