Whether 5.3 cm central type lung cancer can be operated or not needs to be decided according to the patient’s tumor invasion, clinical stage, physical condition and other factors. Central type lung cancer is relatively sensitive in location, located in the hilum, surrounded by the heart as well as large blood vessels. If there is no lymph node metastasis and the relationship with pulmonary artery and pulmonary vein can be peeled off, centralized lung cancer can be surgically resected. If the centralized lung cancer is large in size and seriously invades the surrounding blood vessels and bronchial tubes, surgical resection is not possible. In addition, for advanced central lung cancer, it cannot be cured, and the main purpose is to control the tumor, improve the symptoms and prolong the life. Generally, it is not treated by surgery, and mainly non-surgical treatments such as chemotherapy, radiotherapy, immunotherapy, etc. are mainly used. Moreover, some elderly patients, whose physical state cannot tolerate surgery, generally cannot be treated with surgery. To sum up, for patients with 5.3 cm central lung cancer, they should go to regular hospitals for consultation, and choose appropriate ways of treatment according to their conditions and physical status.