Is there a definite link between the increasing development of human civilization and the increasing incidence of breast cancer worldwide? The answer is yes. Epidemiological studies have found that the incidence of breast cancer is closely related to the level of economic development. The incidence rate of breast cancer in developed countries such as Europe and America is much higher than that in economically backward countries in Asia, Africa and Latin America. Within the same country, the incidence of breast cancer is often higher in economically developed regions than in less developed regions, and the incidence is also higher among people with high cultural level and income level in the same region. Therefore, breast cancer can be largely regarded as a civilizational or modern disease. There are many reasons why the incidence of breast cancer is increasing with the progress of social civilization. First of all, social progress has brought about improvement in nutrition, resulting in earlier age of menarche, later age of menopause and longer menstruation time for women. And these three factors are important factors affecting breast morbidity. Secondly, with the development of society, celibacy, late marriage, late childbearing, no birth, short breastfeeding time or even no breastfeeding after birth are becoming more and more common, and these factors also increase the risk of morbidity. In addition, the increase in the proportion of obese people, the increase in the use of cosmetics (aromatic ingredients, especially nail polish containing phthalates), the increase in the use of health care products related to beauty and body care, and the increase in the proportion of postmenopausal women using estrogen replacement therapy in pursuit of quality of life are all risk factors for the high incidence of breast cancer. The lifestyle of civilized society that does not follow the laws of nature well may be related to the increased incidence of breast cancer. Therefore, following nature may be one of the effective ways to reduce the incidence of breast cancer, while targeting and blocking the influence of these risk factors is a more proactive response. By understanding these facts and taking appropriate measures, the discordant note of high breast cancer incidence may one day cease to exist in a highly harmonious civilized society.