Low back pain that shifts to the buttocks and thighs may be caused by, for example, a lumbar disc herniation. When low back pain is combined with hip and thigh pain, a lumbar disc herniation may have occurred. The intervertebral disc is located between the two vertebrae, and the lumbosacral nerve runs alongside it. The sciatic nerve is made up of the lumbosacral nerve, which runs in the buttocks, the back of the thighs, the back of the calves, and the feet, among other areas. When the lumbar disc bulges or prolapses, it can lead to compression of the sciatic nerve, causing inflammation and edema at the nerve root. The nerve root is stimulated by inflammatory and pain-causing substances, which can lead to symptoms such as low back pain, hip pain and thigh pain. People with severe pain can be treated with oral medications such as Loxoprofen sodium, which can reduce the inflammatory reaction at the nerve root and relieve pain symptoms. If the effect of conservative treatment is poor, consider surgical treatment. When low back pain spreads to the buttocks and thighs, timely medical consultation should be conducted under the guidance of specialists for appropriate treatment, which can help to alleviate the pain and other uncomfortable symptoms as soon as possible.