Zygomatic frontal subluxation is one of the clinical signs of crossed lateral atrophy. Crossed lateral atrophy is extremely rare in clinical practice. How is the disease triggered? The pathogenesis of this disease, like that of facial lateral atrophy, is unknown. It is currently thought to be related to sympathetic dysfunction leading to vasomotor and nutritional dysfunction; it is also thought to be related to facial, cranial or cervical trauma and infection, trigeminal neuropathy, fetal injury or endocrine dysfunction. The lesions slowly progress to half of the face and occasionally to the skull, neck, and contralateral torso. The skin of the affected area is atrophied and wrinkled, often accompanied by hair loss, hyperpigmentation, white scarring, capillary dilation, increased or decreased sweat gland secretion, and sinking of the frontal bone of the zygomatic bone. The common manifestations of cranial MRI include intracranial calcification, brain atrophy, deep and subcortical white matter lesions, cerebral softening, hydrocephalus, meningeal and soft meningeal enhancement, aneurysm, cortical thickening, dysplasia, corpus callosum infarction, etc. There is no good treatment available, and plastic surgery can be used for treatment.