(Disclaimer: This article is for scientific use only, and the information in the following content has been processed to protect patient privacy) Abstract: A 50-year-old male patient came to the hospital with yellowing skin and eyes, accompanied by symptoms of abdominal distension and loss of appetite. Fortunately, the patient’s pathological examination results proved that it was a benign tumor of the pancreas. After complete removal of the tumor, the patient’s abdominal distension and discomfort of upper abdominal fullness disappeared and his appetite improved significantly, and he was discharged from the hospital soon afterwards. The tumor was completely removed, the abdominal distention and discomfort of upper abdominal fullness disappeared, and the appetite improved significantly. The patient was a 50-year-old male with a history of smoking and a history of acute pancreatitis, and he came to our hospital with progressive aggravation of skin yellowing for six months. The patient complained of a generalized yellow staining of the skin and mucous membranes that started six months ago without any obvious cause and became more and more severe, accompanied by abdominal distension and loss of appetite. On physical examination, the sclera was obviously yellowish, and a pigeon egg-sized mass could be found in the upper abdomen on the right side of the center, which was movable without pressure pain. The outpatient blood test showed that the serum bilirubin was as high as 426.4 μmol/L, and the direct bilirubin was mainly elevated up to 265.5 μmol/L. The patient was admitted to the hospital as an outpatient with “jaundice investigation”. The patient was admitted to the hospital and was immediately given CT scan of the chest and whole abdomen and enhanced examination, which showed that the patient had an occupancy of the head of the pancreas, and no significant enhancement was seen on the enhanced scan. The serum carcinoembryonic antigen level was mildly elevated, and CA19-9 level was normal. After hearing that he had an occupying lesion in the pancreas and that pancreatic cancer could not be excluded, the patient immediately broke down emotionally and requested to give up treatment and be discharged home. After reading the patient’s CT images together with the radiologist, we concluded that the occupying pancreatic head was considered to be a benign lesion, and informed the patient of this and repeatedly calmed him down. Minimally invasive surgery was recommended to remove the pancreatic head tumor and relieve the biliary obstruction. After communicating with the patient and his family, he was transferred to the general surgery department for laparoscopic pancreatic segmental resection, and the postoperative pathological examination indicated that the tumor was a plasmacytic cystadenoma of the head of the pancreas, which is a benign tumor of the pancreas. The patient recovered well after the operation, the abdominal distension and epigastric fullness disappeared soon, and the appetite improved significantly. He started to eat liquid diet such as rice soup and porridge 3 days after surgery, and started to transition to semi-liquid diet such as noodles and thin rice 1 week after surgery. The patient was successfully discharged from the hospital 7 days after the operation. One month after surgery, the patient returned to the hospital for follow-up, and the wound was healing well, with no obvious discomfort and no yellowing of the skin and sclera. Six months after the operation, the abdominal CT was rechecked in the outpatient clinic, and no occupying lesions were found in the pancreas and abdominal cavity. We are very glad that the patient’s tumor was benign and the surgery was successful. The patient was advised to pay attention to regular outpatient review after discharge and to return to the hospital for consultation and treatment as soon as possible if there is any discomfort. Therefore, the patient was advised to avoid high-fat diet, avoid spicy and greasy food, focus on light and easily digestible protein diet, and to grasp the principle of eating less and more meals, avoid overeating and excessive satiety, and develop good eating habits to help the patient recover. Personal insight There are few people like this patient who are afraid of cancer, especially pancreatic cancer, but in fact, the occupancy may not always be pancreatic cancer, but may be benign tumors of the pancreas. In addition, as a doctor in charge, it is important to find ways to calm the patient’s emotions and convince him/her to continue treatment when he/she mistakenly believes that he/she has an incurable disease and has an emotional breakdown. The doctor should not only “cure the disease”, but sometimes also “cure the heart”.