Atrophic gastritis is a chronic gastritis characterized by a decrease in the number of gastric mucosal glands. Since moderate to severe atrophic gastritis with intestinal metaplasia or intraepithelial neoplasia can become cancerous, it is called gastric precancerous lesion. Prevention and treatment of atrophic gastritis has positive significance in reducing the occurrence of gastric cancer. What are the predisposing factors of atrophic gastritis? In daily life, eating rough, cold or spicy stimulating food, or drinking alcohol, or emotional fluctuations, or work stress, or drastic changes in climate, etc. can easily lead to the onset of atrophic gastritis. Therefore, these triggering factors should be avoided or reduced in daily life to reduce the attacks of atrophic gastritis. What is the relationship between Helicobacter pylori and atrophic gastritis? H. pylori is one of the causes of atrophic gastritis, peptic ulcer, gastric cancer, and gastric mucosa-associated lymphoid tissue-like lymphoma, and eradication of H. pylori can reduce the incidence of these diseases. So far there is no recognized drug that can reverse precancerous lesions. However, there is a point of agreement that for patients with atrophic gastritis combined with H. pylori infection, the eradication of H. pylori can reverse the atrophy in some patients, which can maintain the stability of intestinalization without further progression, thus reducing the possibility of cancer. What should be noted in the treatment of patients with atrophic gastritis with other diseases? In the treatment of atrophic gastritis with other diseases, it is important to consider whether the medication will cause further damage to the stomach. For example, anticoagulants such as aspirin and clopidogrel are commonly used in cardiovascular diseases, and anti-inflammatory and analgesic drugs such as fenpropathrin and furosemide are used in rheumatic joint diseases, which have certain damage effects on the gastric mucosa. Will it turn into gastric cancer? Gastric cancer does not occur overnight, but through a chronic process from chronic non-atrophic gastritis to chronic atrophic gastritis, followed by intestinalization and/or intraepithelial neoplasia, and finally evolving into gastric cancer. When moderate to severe atrophy and intestinal metaplasia and low-grade intraepithelial neoplasia occur in atrophic gastritis, it should be taken seriously because the chance of developing cancer in these lesions is higher than in the general population, and necessary measures should be taken to prevent the occurrence of cancer. However, there is no need to panic about atrophy and intestinalization. The chance of cancer in atrophic gastritis is still relatively low, about 0.5%-1%, and most of them can be reversed even in low-grade intussusception. Therefore, the prognosis is good for most patients (especially those with mild cases). How to prevent cancer? For patients who have developed atrophic gastritis, regular follow-up gastroscopy and pathological examination is an important tool to prevent gastric cancer. In order to reduce the occurrence of gastric cancer and to facilitate patients and meet the requirements of medical economics, chronic atrophic gastritis with moderate to severe atrophy and intestinal metaplasia should be followed up once a year or so, while chronic atrophic gastritis without intestinal metaplasia or intraepithelial neoplasia can be followed up by endoscopy and pathology as appropriate. In cases with low-grade intraepithelial neoplasia, follow-up is every 6 months, while high-grade intraepithelial neoplasia requires immediate confirmation and endoscopic or surgical treatment after confirmation. For those with combined H. pylori infection, eradication of H. pylori is also an important measure to prevent carcinogenesis. How to maintain a healthy stomach? The key to stomach care is to maintain a regular lifestyle, a positive and optimistic attitude and a healthy diet, with three meals at regular intervals and avoiding hunger and satiety. Gastric patients should pay attention to a low-salt diet, eat more fresh vegetables, avoid overnight vegetables, eat less fried, pickled and barbecued foods, quit smoking, and drink low alcohol in moderation.