The common clinical manifestations of malignant lymphoma include generalized lymph node enlargement, fever, and night sweats. There are four types of fever: low fever (37.5℃-38.5℃, mostly in the early stage of the disease), intermittent fever (fever for a period of time and no fever for a period of time), flaccid fever (temperature fluctuation of 2 degrees or more in a day), and persistent high fever (39.℃ or more). The diagnosis of fever is a complex issue. Hypothermia requires a differential diagnosis with tuberculosis. Intermittent fever requires differential diagnosis with immunoinflammatory diseases such as Still’s disease, Kimura’s disease, and Castleman’s disease, as well as with autoimmune diseases such as rheumatism, dry syndrome, systemic lupus erythematosus, and leukoaraiosis. Flaccid fever needs to be differentially diagnosed from infectious diseases. Hyperthermia requires differential diagnosis with severe infectious diseases, leukemia, necrotizing lymphadenitis, etc. Some patients have fever for months or years before a clear diagnosis is made. During a long period of fever, some doctors apply anti-tuberculosis drugs or many antibiotics to the patient. Some doctors gave the patient intermittent or continuous application of glucocorticoids (commonly called hormones). Some doctors or patients took hormones as antipyretics. This led to misuse of antibiotics and hormones. Hormones have a killing and inhibiting effect on lymphoma, but its use alone is limited or effective with initial treatment, and continued application results in loss of tumor control. Hormones alone cannot cure lymphoma, but rather mask the disease. Hormone abuse is very harmful: 1. Hormone can make lymphoma fever temporarily subside and lymphoma nodes temporarily shrink, but later biopsy cannot make a clear diagnosis due to atypical lymphoma tissue structure or tissue cell necrosis, which brings confusion to the later diagnosis and difficulty to the later treatment. Some doctors have reported tissue disintegration and necrosis, difficult to identify the structure or cell morphology, and difficult to determine the type or source of lymphoma after applying hormones to patients for a period of time to do lymph node biopsy or bone aspiration. 2. Hormones can also shrink lymphomas that are combined with immune inflammation. Clinically, we often encounter that after the application of hormone, the fever is reduced and the lump is shrunken, and the patient often does not seek further treatment, but after a period of time, the fever reappears and the lump increases rapidly again, and finally the lymphoma is diagnosed, but the disease is already at an advanced stage and the best time for treatment is missed. Therefore, hormones should not be taken as antipyretic drugs, and they should be applied with caution and with indications. Hormone abuse is harmful! Hormones should be stopped for more than 5-7 days when taking lymph node biopsy and bone aspiration to prevent confusion of test results.