Parkinson’s disease symptoms include tremor, rigidity, walking difficulties, etc., affecting the patient’s quality of life, the most effective treatment is medication and surgical treatment, generally from the diagnosis of 3-5 years after the start of the medication, the patient will use 2-3 kinds of medication, and there are varying degrees of drug efficacy is reduced, or the emergence of side effects of drugs. The quality of life of the patient is also more affected when there is anisotropy, end-of-dose phenomenon, on-off phenomenon and so on. This is when doctors often recommend that patients be evaluated for surgery and receive surgical treatment when appropriate. In response to the patient’s concern about several issues, Professor Wang Xuelian of Neurosurgery Department of Air Force Medical University gave the main answer. I. When should deep brain electrical stimulation surgery be performed for Parkinson’s disease? Deep brain electrical stimulation surgery should be performed when the following conditions occur: 1, Parkinson’s disease with unsatisfactory adequate drug treatment 2, severe end-of-dose phenomenon and symptomatic fluctuations 3, the emergence of the on-off phenomenon (unpredictable motor fluctuations) 4, anisotropy (dose-peak anisotropy and biphasic anisotropy) 5, pain dyskinesia 6, severe tremor 2, the key to the surgical treatment of Parkinson’s DBS Surgery The key to the surgical treatment of Parkinson’s DBS lies in the preoperative evaluation. The key lies in the preoperative evaluation, the preoperative evaluation mainly evaluates two points: 1, whether it is suitable for surgery; 2, whether it is able to tolerate surgery; for whether it is suitable for surgery, it is necessary to do: cranial nuclear magnetism, Metabolic Shock Test, evaluation of the progress of the disease (analysis of the past condition and history; the speed of the development of Parkinson’s disease and changes in the symptoms of the disease is also an important factor in the evaluation); evaluation of the psychosomatic scale; for the evaluation of whether it is able to tolerate surgery, it is necessary to do ECG, liver function and renal function. For the evaluation of whether the patient can tolerate the surgery, it is necessary to do electrocardiogram, liver function, kidney function and other surgery-related tests to ensure that the patient can tolerate the surgery. Do not wait for Parkinson’s disease to develop serious complications before considering surgery. For Parkinson’s disease patients, the timing of surgery is relatively important. Generally Parkinson’s disease patients in the honeymoon period of drug treatment, wait until the drug has been to the point of exhaustion, has affected the normal life of patients, only to consider surgical treatment, resulting in patients with friends to appear more serious complications, at present, we recommend that the guidance of the diagnosis of Parkinson’s disease in the clinic is recommended or as early as possible surgery, so that you can maximize the improvement of the patient’s symptoms, improve the quality of life, but also can delay the Parkinson’s disease. This can not only maximize the improvement of the patient’s symptoms and quality of life, but also slow down the progression of Parkinson’s disease. What is the effect of deep brain electrical stimulation surgery for Parkinson’s disease? Clinical studies have shown that it has significant therapeutic effects in the treatment of Parkinson’s disease: (1) it can improve the symptoms of tremor, rigidity, slow movement or inability to move, balance disorders, etc.; (2) it can reduce the dose of oral medication; (3) it can improve the quality of patients’ daily life and ability. Experience has shown significant results in patients who respond well to levodopa. Recommendation: Under careful evaluation of efficacy and risk, it is advisable to advance the timing of implantation of DSE, i.e., to consider implantation at the onset of early motor complications, in order to obtain a new therapeutic “honeymoon period”.