Family members of patients often report, “Doctor, it’s okay that he or she has this disease, but he or she always likes to lose his or her temper, argues with me at every turn, and gets angry at the slightest disagreement, I really don’t know what’s wrong with him or her.” The above situation is medically known as a co-morbidity problem in people with epilepsy. Patients with epilepsy often have co-morbidities such as mood disorders, personality changes, insomnia and memory loss. Among mood disorders, the prevalence of depression and anxiety is particularly high, with epidemiological surveys showing that about 30-50% of patients with epilepsy have comorbid depression and anxiety problems. And these mood problems lead to a significant decrease in the quality of life of patients, sometimes even more than the seizures themselves. The reason why patients with epilepsy are prone to mood disorders is because the two disorders share a common pathogenetic basis. For example, lesions in the hippocampus, temporal lobe and frontal lobe of the brain can often be secondary to seizures, and at the same time, these brain areas usually control a person’s emotions, so combined mood problems are more common in patients with frontal and temporal lobe epilepsy. Therefore, if you find that a person with epilepsy has a temper tantrum, do not assume that he or she is being melodramatic, but seek medical attention to rule out comorbid depression or anxiety disorders.