There are several types of drugs for the treatment of Parkinson’s disease: 1. Anticholinergic drugs: These drugs have the ability to inhibit the activity of acetylcholine, correspondingly increase the effect of dopamine in the brain and adjust the balance of transmitters in the striatum. It is suitable for patients with early mild disease and as an adjunct to levodopa. Commonly used drugs are: Antan 2-4mg, 2-3 times/d; Kaimajun 2.5-5mg, 3/d. It has obvious central adverse effects, including memory impairment, confusion, hallucinations, sedation, anxiety, dry mouth, blurred eyes, nausea and other pay effects, and is prohibited for those with glaucoma. 2, dopamine replacement therapy: these drugs to directly supplement the dopamine deficiency in the brain, is currently the best efficacy and well-tolerated treatment drugs among all anti-Parkinsonian drugs. There are levodopa and extracerebral dopa decarboxylase inhibitors: benserazide and carbidopa. The former is a combination of levodopa and benserazide, which has a fast onset and strong effect with a short duration; the latter is a combination of levodopa and carbidopa, which has a weaker effect than methyldopa but a longer duration of action. 3.Dopaminergic receptor agonists: these drugs act directly on the dopamine receptors on the striatum to play a therapeutic role, can be combined with levodopa or applied when levodopa fails, it can delay the application of levodopa and the possible neuroprotective effect, now tend to be used in the treatment of early patients, especially for young patients with onset before 40 years old. There are bromocriptine, xylazine, Tysudar, pramipexole (senfuro), ropinirole, cartegolide, rotigotine, etc. 4, B-type monoamine oxidase inhibitors: dopamine is oxidatively degraded in the brain by monoamine oxidase B, and a large number of toxic oxygen radicals are generated during its degradation to damage neurons. Therefore, inhibiting the activity of MAO-B can both prolong the residence time of dopamine in the brain, enhance the efficacy, reduce the dosage of levodopa and its side effects, and indirectly play a role in protecting neurons. There are selagiline (Sigfranc, Midolpir, Kingspin), Resagiline, etc. 5.Catechol-oxygen-site methyltransferase inhibitor (COMT): catecholamine oxygen-site methyltransferase is an enzyme widely present in human body, which works together with monoamine oxidase in brain to break down and metabolize dopamine, if the activity of this enzyme is inhibited, the degradation of levodopa and dopamine in body can be reduced, so that levodopa can enter the brain more and be converted into dopamine, and also prolong the the time that dopamine is in the brain. There are tolcapone (answer is beauty), entocapone (Kodan), etc. 6. Amantadine. It can enhance presynaptic synthesis and release of dopamine, reduce the reabsorption of dopamine, and also has anticholinergic effects. Can be used in combination with anticholinergic drugs or levodopa. 7, neuroprotective agents: vitamin E and coenzyme Q10, etc.