Cough with sputum and fever are usually seen in respiratory infections, including upper respiratory tract infections and lower respiratory tract infections. For example, cough with sputum and fever can be seen in common cold, cough with sputum and fever can be seen in acute tonsillitis, and cough with sputum and fever can also be caused by bronchitis and pneumonia. Therefore, it is necessary to make a judgment in combination with clinical accompanying symptoms. If there is a sore throat, it is most likely to be an infection of the upper respiratory tract. If there is pus and yellow sputum with chest discomfort or chest pain, it is more likely to be an infection of the lower respiratory tract. Therefore, if you have cough with sputum and fever, you should improve blood analysis, chest X-ray or CT lung examination to clarify and give appropriate treatment. If it is a bacterial infection, treatment with antibiotics including amoxicillin, cefuroxime and other drugs is required. If it is a viral infection, supportive symptomatic treatment, i.e., cough expectorant and fever reducing treatment, will be given.