I. Family history and breast cancer-related genes.
Nowadays, the genes that can clearly lead to breast cancer predisposition are found to be mainly as follows.
1, P53 oncogene mutation.
2. BRCA-1 and BRCA-2 gene defects: This gene defect can lead to high incidence of familial breast and ovarian cancers. The internationally famous movie star Angelina Jolie has BRCA-1 and BRCA-2 gene defect. Jolie is a BRCA-1 gene defect.
Reproductive factors.
1. Age of menarche – the earlier the risk, the more dangerous.
2. The later the age of menopause, the more dangerous it is.
3, menstrual cycle – the shorter the more dangerous.
4. Age of first full-term pregnancy – the later the risk.
5. The number of births – the fewer the number of births, the more dangerous.
6. Breastfeeding history – the shorter the history, the more dangerous.
Sex hormones.
1. Endogenous and exogenous estrogens – the more the risk.
2. Androgens (can be converted into estrogen by directly promoting breast cancer cell
The more androgens – the more the risk, the more the risk.
3. Lactogen – the more the risk, the more the risk.
4. Other hormones – insulin-like growth factor is now found to be positively associated with the development of breast cancer.
Diet and nutrition.
Fat and high-calorie diet can increase estrogen levels in the body.
Alcohol – Women who drink alcohol more than 2-3 times a day have increased estrogen levels and increased risk of breast cancer.
3.Fiber – fiber has an inhibitory effect on breast cancer.
4.Micro-nutrients-Foods rich in vitamin A are found to have a protective effect on breast cells, such as soybean products.
V. Other environmental factors.
1.Ionizing radiation-radiation can damage the body’s DNA, especially during adolescence.
2, drugs – chemotherapy drugs, a variety of drugs for hypertension (Risperdal, phenothiazine, methyldopa, etc.).
3, physical exercise – protective factors.
4.Occupation – Some studies found that occupations with long-term exposure to chemicals (such as beauty industry, drug manufacturing, etc.) have a higher incidence of breast cancer.
6.Other system diseases and breast cancer.
Some diseases have been found to increase the risk of breast cancer, the most representative of which is type II diabetes, insulin resistance and hyperinsulinemia.