Gastric ulcers and duodenal ulcers are the two most common types of peptic ulcers, and their clinical manifestations are extremely similar, mainly manifesting as epigastric pain. The difference between specific gastric ulcer and duodenal ulcer pain is mainly manifested in the following aspects: site of onset: duodenal ulcer occurs in the duodenal mucosa and gastric ulcer occurs in the gastric mucosa. Since the stomach and duodenum are located at different sites, the pain of gastric ulcer is mostly located in the middle or to the left under the saber, while the pain of duodenal ulcer is mostly located in the middle or slightly to the right of the epigastrium. Pain pattern: gastric ulcer pain mostly appears half an hour to 2 hours after meal, lasts 1~2 hours, and disappears before the next meal, which is called “postprandial pain”. The reason why gastric ulcer “postprandial pain” is because after eating food into the stomach, directly stimulate the ulcer surface, and cause muscle spasm and peristaltic hyperactivity of the stomach, so that the muscle tension of the ulcer site increased, thus causing pain. In addition, the stomach is stimulated by the food and the secretion of gastric acid increases, causing pain. Once the chyme is emptied, the above activities of the stomach are weakened and the pain is relieved. In contrast, duodenal ulcer pain mostly appears 3~4 hours after meal and lasts until the next meal, after eating the pain can be reduced or relieved, so it is called “hunger pain”, some can also appear at night, also called “night pain”. The appearance of “hunger pain” and “nocturnal pain” is related to the secretion of gastric juice and the mechanical functional movements such as gastric filling and emptying. The pain is caused by the direct action of gastric acid on the lesion, and after eating, the gastric juice is diluted, thus reducing the stimulation of the gastrointestinal tract and relieving the pain. Therefore, the difference between gastric ulcer and duodenal ulcer pain is mainly manifested in the above two aspects, but the specific distinction between gastric ulcer and duodenal ulcer cannot be distinguished by its pain alone, and the clinical diagnosis still depends on gastroscopic examination.