Urinary closure refers to the 24-hour urine volume is less than 100mL or 12 hours without urine, severe cases can lead to urinary closure. Urinary closure is a disease in which difficulty in urination is the main cause, and in severe cases, no urine is discharged, and there is unfavorable shortness of urine as the symptom. Mainly due to the bladder failure, other organs can also lead to this disease, the upper burns fire, gas loss Xiaodong, the waterway can not be transported down to the bladder, the heart has heat can also occur in this disease. It is mostly seen in patients with severe shock and acute renal failure. Treatment: 1, the treatment of urinary incontinence should be particularly cautious, especially the use of drugs with nephrotoxicity, the dosage, method and course of treatment should be appropriate to prevent damage to the kidneys. Aminoglycoside drugs, such as gentamicin, kanamycin, etc. are prohibited. 2, the treatment of urinary closure should first pay attention to the treatment of underlying diseases, remove obstruction factors, encourage patients to drink more water. 3, on the female urinary closure can try to use a small amount of local estrogen, may be beneficial to restore the physiological state of the lower urinary tract. 4, at present, it is generally believed that, regardless of the presence or absence of symptoms, all patients who are first found to be urinary closure should be given a single course of antibiotic therapy. Drugs can be selected according to the bacteria in urine culture and drug sensitivity to actively control the condition. Prevention: 1, timely urination: when urinating, the urine will be the urethra and vaginal opening of the bacteria flushed out, there is a natural cleaning effect. 2, to avoid contamination: cause urinary closure of the bacteria is most common is E. coli, under normal circumstances, it is parasitic in the intestinal tract, and does not cause disease, but if by the anus into the urethral opening, it will lead to inflammation of the urethra, so after the bowel movement with a clean toilet paper to wipe, to be in order from front to back to avoid contamination of the vaginal opening, if the restroom has a flushing device, it is best to carefully rinse the anus area. 3, supplemental vitamin C: vitamin C can increase the acidity of urine, so that a variety of bacteria that induce urinary tract infections are not easy to survive, so drink more orange juice, citric acid, kiwi juice and other vitamin-rich beverages on the prevention of urinary tract infections is beneficial.