The use of vitamin B1 used to be mainly used for the prevention and treatment of vitamin B1 deficiency, but now it is commonly used clinically for the treatment of insomnia and fatigue, because vitamin B1 can regulate the function of plant nerves, reduce the excitability of the cerebral cortex, and have the effect of promoting sleep and anti-fatigue. In addition, people also use vitamin B1 to prevent and treat lead poisoning, taking 30 mg three times a day, which has obvious effect of lead detoxification. Experts believe that the lead excretion effect of vitamin B1 is to promote the excretion of lead through the formation of complexes between vitamin B1 or its metabolites and lead. As with all drugs, there are precautions for the use of vitamin B1. The following are the “seven dos and don’ts” that people must pay attention to when taking vitamin B1 orally. It is not advisable to take vitamin B1 before meals, and taking it after meals is beneficial to its absorption. Because vitamin B1 is water-soluble, it will be quickly absorbed into the blood after taking it on an empty stomach, and will be excreted by the kidneys before the body can use it, so that the drug cannot fully play its role. Vitamin B1 is unstable in alkaline environment and will be decomposed quickly, which will damage it and reduce its potency or invalidate it. It is not suitable to combine with aspirin. Aspirin is hydrolyzed to salicylic acid in the stomach. Vitamin B1 can lower the pH value of gastric juice and increase the irritation of aspirin to gastric mucosa. Therefore, the two should not be taken at the same time. Vitamin B1 can be adsorbed by medicinal charcoal and reduce the effectiveness of the drug. If the combination is necessary, take vitamin B1 orally first and then take medicinal charcoal 2 to 3 hours later. It is not suitable to combine with oral contraceptive pills Oral contraceptive pills can accelerate the metabolism of vitamin B1 and reduce the concentration of vitamin B1 in the blood. Long-term oral contraceptive pill users should take appropriate vitamin B1 supplements to prevent vitamin B1 deficiency. It is not suitable to combine with Chinese patent medicines containing tannin. Chinese patent medicines such as Four Seasons Qing Tablets, Tiger Balm Infusion Tablets, Compound Qianrihong Tablets, Cold and Flu Tablets and Qilisan contain tannin, which can combine with vitamin B1 to produce precipitation, making it difficult to be absorbed and utilized, and can deteriorate vitamin B1 and reduce its effectiveness.