We have seen many epilepsy patients spend a lot of energy and money to cure the disease, but it is not cured for a long time, the reason is that in addition to a small number of really intractable epilepsy, a considerable part is caused by improper treatment. The reasons for this are: ① Misdiagnosis: including misdiagnosis and misjudgment of seizure type. Some patients diagnosed with epilepsy are not epileptic at all, but other patients, including non-epileptic seizure disorders, such as hysteria, extrapyramidal disorders, sleep disorders. Some antiepileptic drugs can aggravate seizures, such as carbamazepine and phenytoin sodium. The amount of medication is not enough to control the seizures, so the best dose should be found according to the principle of individualization through efficacy observation and blood concentration monitoring. Some drugs poisoning make seizures become frequent and lead to drug-derived seizures, but they are often misjudged as insufficient dose and blindly increased, such as phenytoin sodium poisoning. Some people like to treat epilepsy with a variety of drugs together, adding a little of each, which is very wrong, which not only can not control seizures but also increase the interaction between drugs, easily lead to poisoning and drug resistance, and some even lead to drug-derived seizures. This is the most abhorrent practice. The actual effect is often the western medicine component; most of the western medicines are drugs with high side effects and obvious cognitive damage, and these anti-epileptic drugs are gradually being eliminated in recent years; because the composition and dosage of the adulterated drugs are unknown, it is easy to cause poisoning or reduce the efficacy of other drugs due to drug interactions. The effect of other drugs is reduced due to drug interactions. The so-called “pure Chinese medicine” may be effective at the beginning, but it often fails after a long time because of its own induction or drug-induced tolerance, which may affect the efficacy of other drugs. The best way to achieve the desired therapeutic effect is to arrange the medication schedule so that the peak blood concentration time covers the expected seizure period. The most important thing is to have a good understanding of the situation. Otherwise, it will not only fail to control seizures but also lead to cross-tolerance of drugs. This phenomenon often occurs due to the lack of comprehensive knowledge of epilepsy diagnosis and treatment by medical personnel. If patients who are under treatment and have their seizures fully controlled with medication are discontinued and relapse, the course of medication will have to be counted from the beginning. (7) Failure to avoid triggers and good adherence: Not taking medication as prescribed and avoiding triggers, reducing or stopping medication, or changing the time of taking medication on your own. Doctors should help patients find the triggers and ask them to avoid them; if necessary, check blood levels to check compliance. The above mistakes often lead to seizures that cannot be effectively controlled and the disease is prolonged, resulting in chronic intractable epilepsy and even chronic epileptic encephalopathy. The outcome of this group of patients may be very different after the diagnosis is established and the individualized program of treatment is reasonably adjusted. The most important thing is to make sure that the patient has a good understanding of the situation. This group of patients with refractory epilepsy can consider new antiepileptic drugs or ask surgeons to assist in their treatment under the guidance of specialists.