To understand the effect of tubal effusion on the outcome of in vitro fertilization and the optimal treatment plan. We retrospectively analyzed the clinical data of 136 cases of all patients with tubal infertility using the long protocol who underwent IVF-embryo transfer from September 2001 to December 2002 in our hospital. 49 cases with tubal effusion, who received 52 cycles of treatment, were treated with antimicrobial agents and/or effusion aspiration and/or uterine fluid aspiration, and were the observation The 87 cases without hydrosalpinx received 92 cycles of treatment and were the control group. The response to ovulation promotion, embryo implantation rate, clinical pregnancy rate, early miscarriage rate and incidence of ectopic pregnancy were compared between the two groups. In the observation group, the total number of FSH branches, the number of eggs obtained, the number of fertilization, the implantation rate, the pregnancy rate and the early miscarriage rate were 46.54, 19.42, 12.83, 16.1%, 41.2% and 14.3%, respectively, while the total number of FSH branches, the number of eggs obtained, the number of fertilization, the implantation rate, the pregnancy rate and the early miscarriage rate in the control group were 46.01, 18.31, 11.41, 17.5% and 40.7%, respectively. 17.5%, 40.7%, 10.8%, with similar results; the incidence of ectopic pregnancy was 14.3% in the observation group and 8.1% in the control group, and there was a trend of increase in the observation group, but it was not statistically significant. There was no adverse effect of comprehensive treatment of hydrocele on the outcome of in vitro fertilization.