Patient: Two months ago, the pain in the third vertebrae of the posterior spine and the left hip was slightly uncomfortable. Zhao Hui, Department of Medical Oncology, Shanghai Sixth People’s Hospital: From the description of your symptoms, there should be other parts of the bone destruction, I wonder how the results of the whole body bone scan? The pathology of bone puncture suggests that it is a medium-low differentiated adenocarcinoma with some of the printed cells, and we believe that the pathological diagnosis is the gold standard diagnosis, and the diagnosis of malignant tumor should be clear. As for the specific site, we should further exclude gastric and intestinal sources, and ultrasound endoscopy is feasible to clarify, but we also need to pay attention to the Indolent cell lymphoma, and suggest to perform pathological immunohistochemistry and PET/CT examination if necessary. However, it is still necessary to be psychologically prepared for not finding the primary lesion, because after all, 17% of unexplained metastatic tumors exist.