You can’t take medicine on an empty stomach because some drugs have strong irritating ingredients that can stimulate the mucous membrane of the stomach to produce discomfort, such as nausea, vomiting, abdominal pain and other symptoms, but also easily aggravate the adverse reactions to drugs such as allergies or hypoglycemia. People with bad stomachs eat drugs that are more irritating to the stomach before meals, such as ibuprofen, amoxicillin and other anti-inflammatory painkillers, which may aggravate the erosion and damage of the gastric mucosa and also cause excessive secretion of gastric acid, resulting in painful sensations from gastric acid burning the gastrointestinal mucosa. And eating fat-soluble drugs on an empty stomach will affect the absorption of drugs such as vitamin D, vitamin E and vitamin K. It is recommended to take them with or after meals. In addition, some drugs, such as amoxicillin, can have some adverse reactions, and taking them after meals can effectively reduce the adverse reactions of such drugs, while taking them on an empty stomach can lead to an increased chance of allergic reactions such as rashes and itching. In addition, there are some drugs that are strictly prescribed to be taken after meals, such as metformin hydrochloride tablets and other hypoglycemic drugs, if taken on an empty stomach, it is easy to lead to the occurrence of hypoglycemia, and bring serious consequences. However, not all drugs need to be taken after meals, some specific drugs must be taken before meals, such as drugs to protect the stomach. Gastric drugs taken before a meal can form a protective film on the stomach, thus reducing the irritation of food on the gastric mucosa. In addition, less irritating proprietary medicines can also be taken before meals and are less likely to cause uncomfortable symptoms. If you experience significant discomfort after taking medication on an empty stomach, drink plenty of warm boiled water to help dilute the medication to relieve discomfort, and if necessary, go to the hospital for treatment.