Patient: Description of condition (onset, main symptoms, hospital visited, etc.): I sprained my right ankle in ’03 and have had pain once a year for a week in winter since then. In May this year, the pain reoccurred, the ankle was slightly red, and there was fluid on the MRI with a slight fever. It improved after two weeks. Then the right knee became slightly red, swollen and slightly feverish. On October 15, the onset of the disease again moved to the left ankle [uninjured] with pain, no swelling, and a slight fever [37.8]; it was accompanied by pain in the lower leg and difficulty moving. There is a pins and needles sensation. Hospital: Synovitis. Injections of sodium vitaminate Oral anti-inflammatory and analgesic medication The effect is average Two weeks to recover health. In fact, it is to take anti-inflammatory and analgesic drugs and rest at home for about a week to recover. After many hospital examinations [at the time of the onset of the disease], the MRI showed only fluid accumulation, no abnormal bone quality, and no deformation. When I was not sick, all the tests were basically normal. I would like to ask for your help. 1: What specific tests are needed to determine the cause of the disease? 2: Is there any treatment that can remove the root cause of the disease and cure it once or more? Supplementary: General physical examination 1 fatty liver with high cholinesterase? High blood lipids 2 low HDL cholesterol 3 high uric acid 500 – 560 4 high inorganic phosphorus. Luo Dianzhong, Department of Orthopedics, The First Affiliated Hospital of the PLA General Hospital: According to your description, it is likely to be gouty synovitis. Based on: young male; redness and swelling of the right knee joint with fever; can be transferred to the left ankle; very high uric acid. Carefully recall that there may have been improper diet (eating seafood, drinking beer, or eating animal offal and other high purine diet) within 1 week before the onset of the disease Treatment measures: 1. Strictly control the diet, low purine diet (a search on the Internet all know); 2. Oral NSAIDs drugs in the acute phase (Fotarim, Fenbendazole, Celecoxib, Daphne, etc. choose one) 3. Oral drugs in the chronic phase to control blood uric acid 4. Joint fluid extraction, in 5.If it is confined to the knee or ankle joint and recurrent, arthroscopic surgery is feasible to clean it up and confirm the diagnosis at the same time.