Impotence caused by smoking can be treated by lifestyle changes, use of medication, surgery and physical therapy. 1. Lifestyle change: Smoking affects the function of vascular endothelial cells in the penis, which leads to impotence. Therefore, patients should strictly quit smoking, and control their weight and increase physical activity to improve vascular function. 2. Use of drugs: on the basis of lifestyle changes, patients also need to follow the doctor’s instructions to use sildenafil, tadalafil and other phosphodiesterase type 5 inhibitors, endocrine function abnormalities, testosterone undecanoate can be used in the preparation, in addition, the patient can also use prostaglandin, phentolamine, etc., to promote penile erection. 3. Surgery: If conservative treatment is ineffective or the treatment effect is unsatisfactory, after the doctor’s evaluation, prosthesis implantation and penile revascularization can be chosen to restore or improve the erectile function. 4. Physical therapy: such as vacuum erection device, low energy extracorporeal shock wave therapy, etc., can also assist in the treatment. Most impotence patients can usually be cured through active and standardized treatment. It is recommended that patients visit hospitals in time and receive treatment as early as possible so as not to affect their physical and mental health.