The forehead, between the eyebrows, and the nasolabial folds are key areas for facial rejuvenation surgery, while depressions on the face and neck are also common in clinical practice. How to solve these critical problems quickly, safely and “scarlessly” has always been of great concern. There are many ways to treat wrinkles on the forehead, between the eyebrows, nasolabial folds, and soft tissue depressions in the face and neck. Traditional surgical methods are effective, but they are more traumatic, have more complications, take longer to recover, and leave significant scarring. Although biological wrinkle removal or bio-derivative injection filling is simple, less invasive and easy to operate, there are also disadvantages such as toxic side effects, allergy, rejection and unsustainable effect. After years of continuous research and improvement by scholars at home and abroad, autologous fat injection has become a mature technology and the treatment effect has been greatly improved, so it has gradually become one of the hot methods in international medical aesthetics and is now widely used in the fields of facial depression filling and breast augmentation. In recent years, there are even examples of fat filling surgery using autologous fat injection to augment the back of the hand and the middle of the face, which can make the treated area look more youthful and natural. Some researchers believe that the decreasing amount of adipose tissue in the body with age is the main cause of sagging skin and reduced skin elasticity, and predict that the restoration of subcutaneous volume in the face represents a future trend in the field of facial rejuvenation treatments. The widespread application of fat filling will bring the development of cosmetic surgery into a higher realm. After continuous technical improvement, our department has applied self-designed “micro-needle knife” plus autologous particulate fat transplantation to fill the wrinkles between the eyebrows, nasolabial folds, forehead wrinkles and depressions in various parts of the face and neck, etc. We have treated hundreds of patients, and combined with facial liposuction and fat “transplantation “We have successfully performed facial reshaping in combination with facial liposuction and fat transplantation. It can be widely used for the treatment of soft tissue depressions in various parts of the body, especially in the face and neck, and wrinkles in the forehead, between the eyebrows and nasolabial folds. In addition to the advantages of simple, fast, inexpensive, safe, non-rejection, no scar, and quick recovery of autologous fat transplantation, it also has the following features: ① Enhanced surgical effect. The use of homemade small needle knife, its front end size is equivalent to a thicker injection needle, it can break the “fiber adhesion” between the dermis and its underside, so that the local “adhesion” is loosened, making filling easier and the effect is more obvious; and the filling of its own particles of fat, both This will greatly reduce the possibility of re-occurrence of “adhesions” and thus maintain the durability of the effect; ② reduce the occurrence of complications. Although the small needle knife crossed, radial cutting, but it is impossible to completely break off, more or less will remain a few adhesions, and play a certain role in holding, so it can avoid or reduce the local contraction of the skin or its underlying fiber contracture, hyperplasia and injection of fat caused by excessive local augmentation; ③ patients easy to accept, the effect is long-lasting. The disadvantage is: sometimes it needs to be filled again or more times. The complication rate of autologous fat grafting is very low, about 0.5%, mainly infection, hematoma, hard mass, fat liquefaction, fat absorption, etc. This technique is characterized by low cost, easy operation and extraction, no obvious traces left behind, and long-lasting results.