Cancer pain, or advanced cancer pain, is one of the main causes of suffering for patients with advanced cancer. However, some patients with cancer pain still have severe pain after strict application of the “three-step drug treatment plan”, or they cannot accept the “three-step plan” treatment adequately because they cannot eat, have contraindications to drugs, or cannot tolerate the side effects of analgesic drugs, or the economic burden of taking drugs is too great, etc. They are called persistent cancer pain or refractory cancer pain. Refractory cancer pains are all indications for minimally invasive treatment. 1. Peripheral nerve block and minimally invasive interventional radiofrequency treatment can often achieve satisfactory results by blocking peripheral nerves with different concentrations of local anesthetic drugs or destroying nerves with radiofrequency. It is mainly used for limbs with more limited pain sites. Such as the head and face, extremities, superficial thoracic and abdominal areas. Commonly used nerve blocks include maxillary nerve, mandibular nerve, auriculotemporal nerve, greater occipital nerve, suprascapular nerve, thoracic nerve, intercostal nerve, femoral nerve, closed foraminal nerve, sciatic nerve and peroneal nerve. 2.Epidural nerve destruction block Epidural block is a method of injecting nerve-destroying drugs into the epidural cavity to block spinal nerve conduction and produce segmental analgesia. Compared with peripheral nerve block, epidural block can block both somatic and autonomic nerves, and the blocking area is larger and more effective. Because the nerve-destroying drug does not directly contact the spinal cord and cauda equina, it acts outside the dura, so the possibility of bladder and rectal sphincter involvement is less than that of subarachnoid block. In addition, the epidural catheter can be used to inject the nerve-destroying drug in several times. The most common symptom of pancreatic cancer is pain rather than painless jaundice. The pain caused by abdominal tumors, especially pancreatic cancer pain, can be painless in about 60-85% of patients by ethanol block of the abdominal plexus. Pharmacologic destruction of the celiac plexus provides excellent relief of epigastric pain and back involvement pain caused by primary and secondary tumors in the abdominal cavity. It is most commonly used for pancreatic cancer and is also effective for tumor-based pain in the distal esophagus, stomach, liver, bile duct, small intestine, proximal colon, adrenal gland and kidney. 4.Spinal cord electrical stimulation technique Spinal cord electrical stimulation technique is a new technique developed in the past 20 years, which replaces the painful sensation at the lesion with a tingling sensation, and has the outstanding advantages of not destroying the nerves, the treatment process is completely reversible and does not affect the motor function of the limbs. It can be called the green therapy in invasive treatment of cancer pain. In the United States, nearly 200,000 patients receive such treatment every year and obtain satisfactory pain relief. This technique can be considered for limb and trunk pain; especially for cancer neuropathic pain that is not well controlled by opioid drugs, it can achieve satisfactory results. 5.Central target-controlled analgesic infusion system The outstanding advantage of this treatment method is that it can achieve the same pain relief effect with one third of the oral dose or one hundredth of the intravenous dose, which greatly reduces the side effects associated with oral or intravenous administration. The system is surgically implanted under local anesthesia, with a catheter placed in the subarachnoid space at one end and connected to a microcomputer-controlled programmable morphine pump at the other. It achieves a single infusion of morphine to support six months of medication. Unlike spinal cord electrical stimulation, it can control pain in multiple areas of the body and has the advantage of personalized drug administration according to the patient’s different time periods and pain levels, which is the most advanced method for the treatment of intractable cancer pain at present. In conclusion, some cancer pain patients have to face tens or hundreds of analgesics every day, but still cannot effectively relieve pain or tolerate the side effects, and suffer from both physical and mental pain, and they are often troubled by the inappropriate treatment methods, hoping for a miracle to happen. The above treatments provide some better ways to control some of the intractable cancer pain.