Nimesulide belongs to the non-steroidal anti-inflammatory drugs, clinical application shows that it has good antipyretic, anti-inflammatory and analgesic effect. However, due to the causes of fever in summer, and according to the different causes of fever and people, can take Nimesulide fever, but also need to be treated specifically. Specifically as follows: First, according to the fever crowd selection 1, if the fever patients for children under 12 years of age, should be prohibited for nimesulide fever. Nimesulide can cause damage to children’s liver and central nervous system. If the pediatric fever, antipyretic drugs should be preferred to acetaminophen, if the child is inflammatory fever, can also take ibuprofen; 2, if the patient is hypertensive patients, should be taken with caution. Nimesulide is a non-steroidal anti-inflammatory drug, which may lead to new-onset hypertension or exacerbation of hypertension and increase the incidence of cardiovascular disease. Therefore, patients should follow medical advice and closely monitor blood pressure when taking this type of drug; 3, if the patient is diabetic, because nimesulide can affect the blood concentration of sulfonylurea hypoglycemic drugs, so you should avoid the two types of drugs taken at the same time to avoid hypoglycemia; 4, patients with hepatic dysfunction, you should avoid taking nimesulide. Because the hepatotoxicity of nimesulide is 1.3 times that of other NSAIDs, and the occurrence of serious liver damage is 1.9 times that of other NSAIDs, so patients should avoid taking it; 5, if the female patient is in the period of pregnancy or breastfeeding, because nimesulide has not yet been formally whether or not it has a toxic effect on the fetus or the baby, so during this period should be prohibited from taking this drug. Second, according to the cause of fever selection Nimesulide is mostly used in respiratory tract infections fever, for respiratory tract infections caused by fever, Nimesulide’s antipyretic effect is good, fast-acting. However, there are many causes of fever in summer, besides respiratory tract infections, it also includes heat stroke and unexplained fever. For other causes of fever, the drug should not be used blindly to avoid toxic side effects.