Question 1: Can Parkinson’s disease be cured? Parkinson’s disease cannot be cured! Parkinson’s disease is a degenerative degenerative disease of the nervous system that occurs in middle-aged and elderly people. The primary site of lesion is the substantia nigra in the brain. The dopaminergic neurons in the substantia nigra become degenerative and necrotic, and their number decreases. Symptoms begin to appear when the number of such neurons decreases to a certain level. As time progresses, the number of remaining dopaminergic neurons becomes less and less, and the symptoms become more and more severe. Our current medication and surgical treatment can only improve the patient’s symptoms, but cannot cure the disease. Question 2: How far along do I need to be before I consider surgery? For most patients with Parkinson’s disease, levodopa treatment is effective in the early stages of the disease, with significant improvement in symptoms after taking the medication, and this period lasts for about 4-5 years. As the disease progresses and the drug dose increases, motor complications gradually appear and the impact on the quality of life gradually worsens. Overseas clinical trials have confirmed that early Deep Brain Stimulation (DBS) surgery for motor complications can give full play to the long-term efficacy of DBS, and DBS treatment is expected to reduce the dose of levodopa and reduce the impact of motor complications while improving motor symptoms and motor complications. However, due to the limitations of medical level and economic and social conditions, domestic patients with Parkinson’s disease are usually considered for surgery only in the advanced stage of the disease. The more severe the symptoms are at the time of surgery, the less effective the surgery is in improving the symptoms. Therefore, my recommendation is that surgery should be considered when medications fail to achieve satisfactory results. Appropriate advancement of DBS treatment, while weighing the risks and benefits, allows patients to fully benefit from the long-term efficacy of DBS during the limited course of the disease. Question 3: Is brain surgery very risky? Deep brain electrical stimulation is a stereotactic procedure with minimal surgical trauma. The surgery utilizes advanced equipment such as MRI, electrophysiological recording instruments, directional instruments and neuronavigation, which can avoid important neurovascular and avoid blindness, and the scope of the surgery is within 1mm, which is minimally invasive. The chance of cerebral hemorrhage after surgery is less than 1%. Question 4: Can the elderly tolerate the surgery? Deep brain electrical stimulation surgery is a two-step procedure: the first step is intracerebral electrode implantation. During this procedure, the patient is under local anesthesia, so the patient is awake most of the time, and the procedure takes about 2-3 hours. The second step is the implantation of a pulse generator in the chest. During this procedure, the patient is intubated with general anesthesia and the procedure takes approximately 1 hour. For most patients, it is safe for the elderly to tolerate this procedure in general, as long as they do not have more serious heart, brain, or lung disease.