Tumor-induced fatigue is called cancer-related fatigue (CRF), and is one of the most common symptoms in patients with tumor. CRF is a series of subjective fatigue feelings, such as weakness, intolerance of activities, inability to concentrate, reduced motivation or interest, etc. It occurs in patients of all ages and persists for a long time in the process of tumor treatment and recovery, which consumes a lot of patients’ energy and seriously affects their nutrition and functional status. It is believed that 80% to 99% of tumor patients are suffering from cancer. Currently, it is believed that 80% to 99% of patients receiving chemotherapy, 65% to 100% of patients receiving radiotherapy, and 33% to 89% of patients with advanced tumors have experienced fatigue. Compared to fatigue in healthy individuals, tumor-related fatigue is more severe, lasts longer, and does not resolve with rest. Even those tumor-free people who are no longer receiving treatment may continue to have this fatigue months or years after they stop treatment, with a fatigue rate of 17% to 21% in this group. Tumor-related fatigue is generally considered to be related to the tumor itself and tumor-related treatment. 1, tumor consumption caused by the reduction of body mass: the protein, sugar and fat metabolism of malignant tumor patients have been changed to a great extent, and the utilization rate of food is reduced; the growth of tumor cells causes the increase of energy consumption of the body; various reasons cause the loss of appetite, nausea and vomiting to reduce food intake. All these make the energy supply of the body less than the energy needed by the body, thus causing fatigue. Some tumors will also cause neuroendocrine abnormalities, biochemical and hematological abnormalities, which will also aggravate the fatigue. 2.Treatment factors: tumor patients may feel extremely fatigue during surgery due to surgical trauma and anesthesia factors after surgery, most of them need at least 1 month after surgery to recover to preoperative energy level, some of them need 3-6 months or longer to recover; patients receiving chemotherapy usually feel fatigue in the first few days of chemotherapy; patients receiving radiotherapy feel more and more fatigue with the increase of radiation field and radiation dose. Biological therapy such as interferon, interleukin, monoclonal antibody, etc. can also cause fatigue to different degrees while fighting against tumor. 3. Psychological factors: The diagnosis and treatment process of tumor as well as patients’ worry about prognosis will lead to a series of mental and psychological adverse reactions, such as insomnia, depression, tension, irritability, fear, emotional disorder, sadness, etc. These psychological factors are an aggravation of fatigue. For tumor-related fatigue, the international medical community has given a lot of attention and treatment. A panel of experts in the National Comprehensive Cancer Network guidelines recently identified seven factors that frequently contribute to the experience of fatigue, including pain, depression, sleep disturbances, anemia, nutrition, exercise levels, and other comorbidities. Effective management of these factors with pharmacologic and non-pharmacologic treatments can significantly reduce the fatigue state. For fatigue caused by anemia, pain, depression and nutrition in oncology patients, symptomatic treatment with some drugs, such as application of erythropoietin to correct anemia and granulocyte colony-stimulating factor to improve low white blood cells, can have obvious efficacy. Non-pharmacological treatment includes sleep therapy, psychotherapy, exercise therapy and diet therapy. For example, sleep therapy advocates ensuring adequate sleep, reducing daytime sleep time and increasing effective nighttime sleep as a way to reduce patient fatigue caused by biorhythm disturbances. Patients can use some self-regulation methods such as: stimulation control (fixing bed and wake times, avoiding coffee and stimulating activities at night); sleep restriction (avoiding long hours or late afternoon napping, limiting time in bed to obtain normal sleep); more exposure to the natural environment during the day (e.g., walking birds and visiting parks); and establishing an environment conducive to sleep (e.g., dark, quiet, and comfortable). It is important to note that since the primary factor causing fatigue is pain, perfect pain control is an important means of reducing fatigue. In addition to the three-step analgesics prescribed by WHO, non-pharmacological treatments such as transcutaneous electrical stimulation and Han’s instrument, which exert autoregulatory effects by activating endogenous anti-pain substances and anti-fatigue substances in the body, are also beneficial for tumor-related fatigue.