In clinical practice, we often encounter patients with anemia and thrombocytopenia, and for general non-rheumatologists, it is normal to transfuse red blood cells and platelets. However, this transfusion method should be used with caution in connective tissue patients, especially in SLE patients, and some of them are even contraindicated. There was once a patient with SLE who was hospitalized for leukocyte, hematocrit and platelet reduction, and improved significantly after hormone and immunosuppressive treatment, with normal leukocyte and platelet and increased hematocrit, and during the hospitalization, ovarian cysts were detected and transferred to gynecology for treatment, and because of anemia, gynecology immediately gave 1u of concentrated red blood cells transfusion, and the platelet dropped to 20,000 the next day, which promptly stopped the operation and transfusion of blood products, and continued hormone and immunosuppressive treatment. The platelets rose only one week after the treatment. There is also a lesson of immune hemolysis and hemolytic jaundice caused by transfusion of concentrated red blood cells to lupus patients, which eventually made the patients’ lives irreversible. Because there are a large number of auto-antibodies in the body of SLE, including anti-white blood cell antibodies, anti-red blood cell antibodies and anti-platelet antibodies, etc., for example, when you infuse concentrated red blood cells, you also infuse a large number of white blood cells and platelets, which are antigenic substances that react immunologically with the corresponding antibodies in the body of lupus patients, and not only cannot increase the role of red blood cells and hematocrit, but also will get lower and lower, stimulating more serious immune reactions and even causing irreversible jaundice. Instead of increasing red blood cells and hematocrit, the transfusion will become lower and lower, triggering more serious immune reactions and even causing irreversible danger. How to choose blood transfusion when lupus patients need it? If the anemia is really serious, such as autoimmune lysis anemia, which has been treated with corresponding hormones and immunosuppressive therapy, then transfusion of washed red blood cells can be considered, which is healthy blood with all plasma and 90% white blood cells and platelets removed, and metabolites such as potassium, ammonia and lactic acid produced during the preservation process are also removed, and more than 70% of red blood cells are retained, which can avoid artificial immune reactions. Platelets below 20,000 have the tendency of spontaneous bleeding and need emergency platelet transfusion to save life, platelet transfusion can be considered, but it must be transfused under the premise of static propecia ball shock therapy, because static propecia ball has the effect of sealing antibody, which can seal autoantibodies and reduce immune reaction. So be cautious when you encounter connective tissue patients, especially SLE patients, who need transfusion of blood products!