The onset of rheumatoid arthritis is associated with infection with group A beta-hemolytic streptococci, and its clinical manifestations are wandering redness, swelling, heat and pain in large joints such as knee, ankle, elbow, wrist and shoulder, so the treatment mainly includes two parts: elimination of streptococcal infection foci and anti-rheumatic treatment. Anti-streptococcal infection to remove the cause of rheumatic fever is an important measure, penicillin is the drug of choice, if there is penicillin allergy or intolerance, other antibiotics can be considered. Rheumatoid arthritis one of the main manifestations of rheumatic fever, currently oral drug therapy is the main, salicylic acid preparations are the most commonly used drugs. Aspirin is the drug of choice, and other anti-inflammatory painkillers, such as diclofenac sodium and indomethacin, can also be used, mainly to reduce the symptoms of joint redness, swelling and heat pain. If the patient has cardiac lesions and salicylic acid preparations are not effective, glucocorticoids, such as prednisone and dexamethasone, should be considered. In addition, Chinese herbal medicine has a role in the treatment of rheumatoid arthritis, which can control the progress of the disease and improve the symptoms. Therefore, once rheumatoid arthritis is clearly diagnosed, you should come to the rheumatology department as soon as possible and develop a suitable treatment plan under the guidance of rheumatologists, as well as regular follow-up.