Patients with refractory hypertension require reasonable and comprehensive management, mainly the following: 1. Improve lifestyle: improve poor lifestyle, such as quitting smoking, limiting alcohol and limiting salt intake. The World Health Organization requires that each person’s daily salt intake should not exceed 5g, and China is more lenient, requiring a daily salt intake of no more than 6g per person, a wine bottle cap is 6g of salt. For people who eat out a lot or have combined family meals, it is difficult to assess the daily salt intake, so salt measurement can be used, which is to assess the salt intake through urinary sodium excretion. It is also necessary to increase physical activity and control weight. Due to the presence of electronic products, not only young people, in fact, many teenagers and children lack exercise, and the increase in obese children is also on the rise, so physical exercise is also very important; 2, reasonable drug selection: it is recommended that patients go to a specialist hospital, because drug selection, drug mechanisms, drug treatment effects and possible adverse reactions, professional doctors may know better. The treatment of hypertension emphasizes individualized treatment. If the blood pressure is difficult to control, what factors should be ranked, what methods can help to detect and evaluate, and which drug combinations are more appropriate, need to be evaluated by a professional doctor. The more clinically used drugs for hypertension treatment are mainly RAS blockers, including converting enzyme inhibitors; ARB angiotensin receptor antagonists, also known as sartans; and calcium channel blockers, mainly diphenhydramine type of therapeutic drugs. Combination medication for refractory hypertension, often choose different mechanisms of rational use of drugs, angiotensin receptor antagonists and angiotensin-converting enzyme inhibitors can choose one of them, but also calcium channel blockers, there is also about refractory hypertension in, if the patient does not have contraindications to the use of diuretics, generally will add diuretics for the combination of drugs, if blood pressure is still difficult to control, it If the blood pressure is still difficult to control, additional infrequently used drugs are needed, and more specialist evaluation and adjustment of the treatment plan are required.