Patients with chronic urticaria are at greater risk of developing malignancies, according to a recent report in the US dermatology literature, which is based on a retrospective population-based cohort study from Taiwan. The study showed that among 12,720 patients with chronic urticaria (excluding those with autoimmune diseases and a history of malignancy), a total of 704 patients were found to later develop malignancy, with an incidence rate of 5.5%. The majority of malignancies occurred within 1 year after the diagnosis of chronic urticaria, and the age of risk associated with the development of neoplasms in chronic urticaria is mainly between 20 and 39 years; therefore, chronic urticaria of young to middle age should be evaluated clinically accordingly. Chronic urticaria has the highest risk of malignancies of the hematopoietic system, of which non-Hodgkin’s lymphoma is the most frequent, followed by tumors of the brain, retroperitoneum, female genitalia and kidney. It is important to emphasize that the occurrence of these malignancies has excluded patients on long-term immunosuppression, that is, the relationship between the occurrence of malignancies and chronic urticaria has excluded certain cancer-inducing drugs. It is unclear whether the coexistence of chronic urticaria and malignancy is a chance occurrence or whether they share some pathogenetic mechanism.