Most of the lower limb edema that occurs with hypertension medications is caused by adverse reactions to the medication, commonly caused by calcium antagonists, such as amlodipine besylate tablets, nifedipine extended-release tablets or nifedipine controlled-release tablets, and other medications. When lower limb edema occurs, patients are advised to temporarily stop this type of drug therapy and choose other antihypertensive drugs, such as angiotensin-converting enzyme inhibitors or angiotensin II receptor antagonists, such as clinically used drugs like lortensin, temisartan, valsartan, etc., and monitor blood pressure while taking oral drugs. If an antihypertensive drug does not control blood pressure satisfactorily, it can be combined with other drugs, such as beta-blocker betalactam, which is commonly used clinically, and monitor blood pressure, and ask the patient’s past history in detail when taking betalactam, which is contraindicated if there is a history of asthma.