“Precision Medicine,” also translated as “precision medicine,” is a complex concept with rich connotations that requires careful consideration and interpretation. For example, precision medicine cannot be simply equated with “individualized medicine”, because individualized medicine for herbalists is not precision medicine; for example, genome sequencing is one of the main tasks to achieve “precision medicine”, but it cannot be taken to achieve “precision medicine”. For example, genome sequencing is one of the main tasks to achieve “precision medicine”, but we cannot limit the achievement of “precision medicine” to genome sequencing. The emergence of “precision medicine” will have a significant impact on biomedical research and medical practice, and may change the traditional model of human health maintenance and disease fighting. At a time when “precision medicine” is making waves, we need to think about why we are launching a precision medicine program at this time. How can we achieve our goals? According to the authors of Toward Precision Medicine, “The creation of knowledge networks and their research and clinical application depend on the availability of a large, multi-level, fully integrated database of knowledge about human diseases.” In such a database, knowledge about human diseases contains not only phenotypic information such as clinical diagnosis and pathological analysis, but also various biomolecular information, including genome, transcriptome, proteome, metabolome, and epigenome. In other words, the basis for conducting precision medicine is to have the most complete individual biological data possible. Such a database is not a simple collection of biological data of one kind together. If a class of biomolecules or a phenotype is considered as a variable, and the data of the same variable form an information layer, then this database is a multilevel structure consisting of many variables, each layer containing information on one variable related to the disease. The various different types of biological data layers form a close internal connection between them, forming a complex biological knowledge network. This high degree of integration between different kinds of biomolecules and between biomolecules and phenotypes/clinical symptoms will facilitate the discovery of disease-causing factors or diagnostic markers that cannot be tapped by traditional methods, and facilitate the accurate diagnosis and treatment of specific individual patients. “Toward Precision Medicine also suggests that the key to building disease knowledge databases and knowledge networks is “individual-centeredness”. The database needed for precision medicine is to establish a high degree of internal linkage between various types of data obtained from individual patients. How do you build an individual-centered database of data and information? A study published in the journal Cell can serve as a model. A scientist in the United States performed phenotypic monitoring and blood sample analysis for 14 months to obtain a complete “multi-omics” database of individuals, including phenomic profiles, genomic sequences, transcriptomic expression profiles, proteomic expression profiles, and metabolomic expression profiles, and used bioinformatics tools to integrate these different types of data to create a database called the “multi-omics” database. We also integrate these different types of data through bioinformatics tools to create a database called “integrated personal multi-omics profile”. Precision medicine refers to the individualized medical model based on personal genomic information, combined with other biological information, which allows doctors to develop new treatment plans based on personal genomic and tumor patient’s genetic profile in order to maximize treatment effects and minimize side effects.